Jatrolignans C and D: New Neolignan Epimers from <i>Jatropha curcas</i>

Yi-Lin He; Pei-Zhi Huang; Hong-Ying Yang; Wei-Jiao Feng; Zhao-Cai Li; Kun Gao

doi:10.3390/molecules27113540

Molecules (May 2022)

Jatrolignans C and D: New Neolignan Epimers from <i>Jatropha curcas</i>

Yi-Lin He,
Pei-Zhi Huang,
Hong-Ying Yang,
Wei-Jiao Feng,
Zhao-Cai Li,
Kun Gao

Affiliations

Yi-Lin He: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
Pei-Zhi Huang: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
Hong-Ying Yang: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
Wei-Jiao Feng: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
Zhao-Cai Li: State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
Kun Gao: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

DOI: https://doi.org/10.3390/molecules27113540
Journal volume & issue: Vol. 27, no. 11
p. 3540

Abstract

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Two new neolignans jatrolignans, C (1) and D (2), a pair of epimers, were isolated from the whole plants of Jatropha curcas L. (Euphorbiaceae). Their structures were determined with HRESIMS, IR, and NMR data analysis, and electronic circular dichroism (ECD) experiments via a comparison of the experimental and the calculated ECD spectra. Their antichlamydial activity was evaluated in Chlamydia abortus. They both showed dose-dependent antichlamydial effects. Significant growth inhibitory effects were observed at a minimum concentration of 40 μM.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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