Nature Communications (May 2019)

Transient opening of trimeric prefusion RSV F proteins

  • Morgan S. A. Gilman,
  • Polina Furmanova-Hollenstein,
  • Gabriel Pascual,
  • Angélique B. van ‘t Wout,
  • Johannes P. M. Langedijk,
  • Jason S. McLellan

DOI
https://doi.org/10.1038/s41467-019-09807-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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The respiratory syncytial virus (RSV) F glycoprotein forms a trimeric complex and mediates viral entry. Using structures of RSV F in complex with antibodies, Gilman et al. here show a breathing motion of the prefusion conformation of F, resulting in transient opening of the trimeric complex in solution and on the cell surface.