Development of protocols and efficiency of ozone-containing drugs for the treatment of livestock with reproductive pathologies

Abstract

For animals with reproductive pathologies, a comprehensive program treatment that considers the principle of drug action is widespread. One of the essential points of the program is the use of antibacterial drugs. Available drugs have variable activities, some of which have adverse effects. Therefore, the search for the mentioned item of the program of new drugs that would meet the requirements of modern practice is an urgent problem in veterinary medicine that needs to be solved. In this regard, ozone therapy is promising due to its ability to affect the transport and release of oxygen into tissues, disinfectant action, and a wide range of ozone therapy for treating several diseases. Our work aimed at developing ozone-containing drugs for animal reproductive (obstetric, mammalogical, and andrological) pathologies treatment. In the standard protocol, we replaced antibacterial drugs with ozonated corn oil (OCO) and Prozon (complex preparation of ozonated corn oil and alcohol solution of propolis). The recovery process was assessed during and after the therapy by the duration and percentage of recovered animals. In treating animals with subclinical mastitis, the recovery criterion was the normalization of milk cytograms. In the treatment of cows and goats with acute postpartum catarrhal-purulent endometritis, the use of ozone-containing drugs reduced the period from the treatment beginning to the disappearance of clinical signs by 0.7 days (OCO) and 4.8 days (Prozon) and from birth to estrus – by 1.8 and 11.1 days, respectively; while fertility increased by 8.5% and 41.9%. Periods from the beginning of treatment of goats with OCO and Prozon to the disappearance of clinical signs decreased by 1.1 days and 2.8 days, respectively; while fertility increased by 17.2% and 37.2%. Treatment of cows with subclinical mastitis during the dry period with the use of ozone-containing drugs helped to reduce the duration of cure by 1.1 days (OCO) and 2.0 days (Prozon), and the effectiveness of treatment (percentage of recovered animals) increased by 5, 6% and 10.0%, respectively. Treatment of cows with subclinical lactational mastitis reduced the duration of cure by 0.2 days (OCO) and 0.8 days (Prozon), and its effectiveness (percentage of recovered animals) increased by 6.5% and 14.6%, respectively. The ozone-containing drugs for the treatment of nonspecific balanoposthitis in domestic boars reduced the period of recovery by 0.9 days (OCO) and 1.5 days (Prozon), bulls – by 1.1 and 2.7 days, and rams – by 0.8 and 2.2 days, respectively.

Keywords

• cows
• goats
• domestic boars
• bulls
• sheep
• ozone therapy
• endometritis
• mastitis
• balanoposthitis