The Assessment of the Possibility to Use the Coulter's Method (Electrosensitive Zones) for Identification of Invisible Particulate Matter in Human Blood-Derived Products Produced in Russia

Abstract

The article presents the results of the study of the possibility of using the method of electrosensitive zones (Coulter's method) to evaluate the indicator «Particulate matter (invisible)» in domestic medicinal human blood-derived products. The studies were carried out on suspensions of latex particles, the size and quantity of which corresponded to those normalized for parenteral preparations. Suspensions simulated human blood-derived products, which can presumably contain some invisible particles. Factors that can influence the reliability of test results conducted using the method of electrosensitive zones are determined: the electrical conductivity of the test sample, the volume of the analytical sample, the degree of dilution of the sample.

Keywords

• human blood-derived products
• invisible particulate matter
• coulter 's method (method of electrosensitive zones)