Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

Abstract

A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.

Keywords

• microwave-assisted synthesis
• nitrogen-fused heterocycle
• one-pot
• pyrimidinone