Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ

Hua Mao; Pamela Lockyer; Luge Li; Christie M. Ballantyne; Cam Patterson; Liang Xie; Xinchun Pi

doi:10.1038/ncomms14960

Nature Communications (Apr 2017)

Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ

Hua Mao,
Pamela Lockyer,
Luge Li,
Christie M. Ballantyne,
Cam Patterson,
Liang Xie,
Xinchun Pi

Affiliations

Hua Mao: Cardiovascular Research Institute and Department of Medicine, Baylor College of Medicine
Pamela Lockyer: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill
Luge Li: Cardiovascular Research Institute and Department of Medicine, Baylor College of Medicine
Christie M. Ballantyne: Department of Medicine, Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Section of Cardiovascular Research, Baylor College of Medicine
Cam Patterson: New York-Presbyterian Hospital
Liang Xie: Cardiovascular Research Institute and Department of Medicine, Baylor College of Medicine
Xinchun Pi: Cardiovascular Research Institute and Department of Medicine, Baylor College of Medicine

DOI: https://doi.org/10.1038/ncomms14960
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

LDL receptor-related protein 1 (LRP1) is an endocytic receptor involved in cell signalling and energy homeostasis. Here Maoet al. demonstrate that endothelial Lrp1 modulates lipid and glucose metabolism by binding the nuclear receptor Pparγ and promoting its transcriptional activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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