Zaporožskij Medicinskij Žurnal (Feb 2014)

Experience of the use of drugs with thioctic acid in overweight women using combined oral contraceptives

  • N. V. Avramenko,
  • I. B. Gridina,
  • O. A. Nikiforov,
  • E. A. Lomeyko

DOI
https://doi.org/10.14739/2310-1210.2014.1.23642
Journal volume & issue
no. 1
pp. 6 – 8

Abstract

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Introduction Overweight is a serious medical, social and economic problem of the modern society. Today it is established that the level of sexual activity in women is not dependent on the body mass index. Unfortunately, about 40% of patients with overweight stop to receive modern combined oral contraceptives in the first two months of the side effects occurrence. Today it is very important to improve the modern combined oral contraceptives intake by women with overweight. Research objective To compare tolerance to the modern combined oral contraceptives with thioctic acid in women with excessive body weight. Materials and methods 64 patients were divided into two groups. Patients of the 1 group (32 observations) were recommended to use thioctic acid in a dose of 600 mg daily for the first month of reception of a modern combined oral contraceptive containing etinilestradiol and desogestrel. Women of the control group (32 observations) used combined oral contraceptives containing levonorgestrel and desogestrel, but not used drugs with thioctic acid. The results of the research In the course of the observation spotting were noted in 40% of women in both groups. The nausea was observed in 20% of patients of the second group and only in 7% of the patients in the first group. Decreased libido, and mood were observed only in 5% of patients of the first group and in 15% of patients of the second group. Weight gain within2 kgdue to fluid retention was observed in 30% of patients of the second group and only in 10% of the patients of the first group. After the end of the observation 90% of women of the first group and 75% of women of the second group continued to take combined oral contraceptive. Conclusions Use of thioctic acid in a daily dose 600 mg for the first month of intake of the combined oral contraceptive can significantly reduce the frequency of such unpleasant side effects as nausea, decreased libido, and mood, increased body mass index.

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