Nature Communications (Aug 2022)
Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis
- Michael Papanicolaou,
- Amelia L. Parker,
- Michelle Yam,
- Elysse C. Filipe,
- Sunny Z. Wu,
- Jessica L. Chitty,
- Kaitlin Wyllie,
- Emmi Tran,
- Ellie Mok,
- Audrey Nadalini,
- Joanna N. Skhinas,
- Morghan C. Lucas,
- David Herrmann,
- Max Nobis,
- Brooke A. Pereira,
- Andrew M. K. Law,
- Lesley Castillo,
- Kendelle J. Murphy,
- Anaiis Zaratzian,
- Jordan F. Hastings,
- David R. Croucher,
- Elgene Lim,
- Brian G. Oliver,
- Fatima Valdes Mora,
- Benjamin L. Parker,
- David Gallego-Ortega,
- Alexander Swarbrick,
- Sandra O’Toole,
- Paul Timpson,
- Thomas R. Cox
Affiliations
- Michael Papanicolaou
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Amelia L. Parker
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Michelle Yam
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Elysse C. Filipe
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Sunny Z. Wu
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Jessica L. Chitty
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Kaitlin Wyllie
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Emmi Tran
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Ellie Mok
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Audrey Nadalini
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Joanna N. Skhinas
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Morghan C. Lucas
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- David Herrmann
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Max Nobis
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Brooke A. Pereira
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Andrew M. K. Law
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Lesley Castillo
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Kendelle J. Murphy
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Anaiis Zaratzian
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Jordan F. Hastings
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- David R. Croucher
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Elgene Lim
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Brian G. Oliver
- School of Life Sciences, Faculty of Science, University of Technology Sydney
- Fatima Valdes Mora
- Cancer Epigenetic Biology and Therapeutics, Personalised Medicine, Children’s Cancer Institute
- Benjamin L. Parker
- Metabolic Systems Biology Laboratory, Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney
- David Gallego-Ortega
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Alexander Swarbrick
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Sandra O’Toole
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Paul Timpson
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- Thomas R. Cox
- The Garvan Institute of Medical Research and The Kinghorn Cancer Centre
- DOI
- https://doi.org/10.1038/s41467-022-32255-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
The distribution and organisation of matrix molecules in the tumour stroma help shape solid tumour progression. Here they perform temporal proteomic profiling of the matrisome during breast cancer progression and show that collagen XII secreted from CAFs provides a pro-invasive microenvironment.
