Nature Communications (Mar 2019)

Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis

  • Omar Rifaie-Graham,
  • Jonas Pollard,
  • Samuel Raccio,
  • Sandor Balog,
  • Sebastian Rusch,
  • María Andrea Hernández-Castañeda,
  • Pierre-Yves Mantel,
  • Hans-Peter Beck,
  • Nico Bruns

DOI
https://doi.org/10.1038/s41467-019-09122-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 8

Abstract

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Methods to diagnose malaria are of interest but can be costly or not sensitive enough to detect low levels of parasitemia. Here the authors report an ultrasensitive method by using hemozoin (a biomarker of all Plasmodium species) to catalyse the polymerization of N-isopropylacrylamide.