On the Offensive: the Role of Outer Membrane Vesicles in the Successful Dissemination of New Delhi Metallo-β-lactamase (NDM-1)

Melina M. B. Martínez; Robert A. Bonomo; Alejandro J. Vila; Paulo C. Maffía; Lisandro J. González

doi:10.1128/mBio.01836-21

mBio (Oct 2021)

On the Offensive: the Role of Outer Membrane Vesicles in the Successful Dissemination of New Delhi Metallo-β-lactamase (NDM-1)

Melina M. B. Martínez,
Robert A. Bonomo,
Alejandro J. Vila,
Paulo C. Maffía,
Lisandro J. González

Affiliations

Melina M. B. Martínez: ORCiD; Laboratorio de Microbiología Molecular, Instituto de Microbiología Básica y Aplicada, Universidad Nacional de Quilmes, Bernal, Buenos Aires, Argentina
Robert A. Bonomo: ORCiD; Research Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio, USA
Alejandro J. Vila: ORCiD; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA
Paulo C. Maffía: ORCiD; Laboratorio de Microbiología Molecular, Instituto de Microbiología Básica y Aplicada, Universidad Nacional de Quilmes, Bernal, Buenos Aires, Argentina
Lisandro J. González: ORCiD; Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Rosario, Argentina

DOI: https://doi.org/10.1128/mBio.01836-21
Journal volume & issue: Vol. 12, no. 5

Abstract

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Resistance to carbapenems, last-resort antibiotics, is spreading worldwide, raising great concern. NDM-1 is one of the most potent and widely disseminated carbapenem-hydrolyzing enzymes spread among many bacteria and is secreted to the extracellular medium within outer membrane vesicles.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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