Possible risks and benefits of adenomyomectomy on pregnancy outcomes: a retrospective analysisAJOG MFM at a Glance

Seisuke Sayama, MD, PhD; Takayuki Iriyama, MD, PhD; Ayako Hashimoto, MD, PhD; Kensuke Suzuki, MD, PhD; Yu Ariyoshi, MD; Eriko Yano, MD; Masatake Toshimitsu, MD, PhD; Mari Ichinose, MD, PhD; Takahiro Seyama, MD, PhD; Kenbun Sone, MD, PhD; Keiichi Kumasawa, MD, PhD; Yasushi Hirota, MD, PhD; Yutaka Osuga, MD, PhD

AJOG Global Reports (Nov 2023)

Possible risks and benefits of adenomyomectomy on pregnancy outcomes: a retrospective analysisAJOG MFM at a Glance

Seisuke Sayama, MD, PhD,
Takayuki Iriyama, MD, PhD,
Ayako Hashimoto, MD, PhD,
Kensuke Suzuki, MD, PhD,
Yu Ariyoshi, MD,
Eriko Yano, MD,
Masatake Toshimitsu, MD, PhD,
Mari Ichinose, MD, PhD,
Takahiro Seyama, MD, PhD,
Kenbun Sone, MD, PhD,
Keiichi Kumasawa, MD, PhD,
Yasushi Hirota, MD, PhD,
Yutaka Osuga, MD, PhD

Affiliations

Seisuke Sayama, MD, PhD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Takayuki Iriyama, MD, PhD: Corresponding author: Takayuki Iriyama, MD, PhD.; Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Ayako Hashimoto, MD, PhD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Kensuke Suzuki, MD, PhD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Yu Ariyoshi, MD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Eriko Yano, MD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Masatake Toshimitsu, MD, PhD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Mari Ichinose, MD, PhD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Takahiro Seyama, MD, PhD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Kenbun Sone, MD, PhD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Keiichi Kumasawa, MD, PhD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Yasushi Hirota, MD, PhD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan
Yutaka Osuga, MD, PhD: Faculty of Medicine, Department of Obstetrics and Gynecology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan

Journal volume & issue: Vol. 3, no. 4
p. 100265

Abstract

Read online

BACKGROUND: Adenomyosis is associated with unfavorable perinatal outcomes; however, the effect of an adenomyomectomy on pregnancy outcomes remains unclear. Pregnancy following an adenomyomectomy has been reported to be associated with a high risk for uterine rupture; however, the actual incidence remains unknown. OBJECTIVE: This study aimed to evaluate the effect of an adenomyomectomy on pregnancy outcomes by retrospectively comparing the pregnancy outcomes of women who underwent an adenomyomectomy with those of women with adenomyosis. STUDY DESIGN: This was a single-center retrospective study in which the pregnancy outcomes of women who underwent an adenomyomectomy and for whom complete resection of the affected tissue under laparotomy was achieved were compared with those of women with adenomyosis. The following pregnancy outcomes were examined: second-trimester miscarriage, preterm prelabor rupture of membranes, preterm delivery, spontaneous preterm delivery, preeclampsia, rate of cesarean delivery, blood loss during cesarean delivery, incidence of placenta accreta spectrum, neonatal body weight, and small for gestational age infants. RESULTS: A total of 18 pregnant women who underwent an adenomyomectomy and 105 pregnant women with adenomyosis were included in this study. All women who underwent an adenomyomectomy delivered via cesarean delivery, and among them, 1 had a uterine rupture at 30 weeks of gestation. Although there was no significant difference between pregnant women who underwent an adenomyomectomy and those with adenomyosis in the incidence of second-trimester miscarriage (0% [0/18] vs 7.6% [8/105], respectively; P=.22), preterm delivery (50% [9/18] vs 32% [34/105], respectively; P=.15), and spontaneous preterm delivery (6% [1/18] vs 15% [16/105], respectively; P=.26), a significant decrease in preterm prelabor rupture of membrane (0% [0/18] vs 12% [13/105], respectively; P<.05), preeclampsia (0% [0/18] vs 12% [13/105], respectively; P<.05), and small for gestational infants (0% [0/18] vs 15% [16/105], respectively; P<.05), as well as a significant increase in the incidence of placenta accreta spectrum (50% [9/18] vs 0% [0/105], respectively; P<.01) and blood loss during cesarean delivery (1748 mL vs 1330 mL, respectively; P<.05) were observed. CONCLUSION: Uterine rupture following an adenomyomectomy may occur because of the high incidence of placenta accreta spectrum. However, an adenomyomectomy may reduce adverse pregnancy outcomes associated with adenomyosis, such as preterm prelabor rupture of membranes, preeclampsia, and small for gestational age infants. An adenomyomectomy may be a viable option for women among whom the procedure is inevitable before conception.

Published in AJOG Global Reports

ISSN: 2666-5778 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Gynecology and obstetrics
Website: https://www.journals.elsevier.com/ajog-global-reports

About the journal

Abstract

Keywords