Neuropsychiatric Disease and Treatment (May 2023)
Pimavanserin: A Truly Effective Treatment for Parkinson’s Disease Psychosis? A Review of Interventions
Abstract
Beatrice Heim, Marina Peball, Florian Krismer, Atbin Djamshidian, Klaus Seppi Department of Neurology, Medical University of Innsbruck, Innsbruck, AustriaCorrespondence: Beatrice Heim; Klaus Seppi, Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, Innsbruck, 6020, Austria, Tel +43-512-504-81128, Email [email protected]; [email protected]: Parkinson’s disease (PD) is the second-most common neurodegenerative disorder with a long-term 60% cumulative prevalence of PD psychosis. Medical treatment is limited to few atypical antipsychotic drugs with low affinity to dopamine D2 receptors. In 2016, pimavanserin, a selective 5-HT2A inverse agonist/antagonist, was approved by the US Food and Drug Administration (FDA) as the only treatment for PD psychosis (PDP). This article provides an overview of the epidemiology, pathophysiology, and treatment options for PDP and illuminates the mode of action and therapy options with pimavanserin and the current study data.Keywords: Parkinson’s disease, psychosis, pimavanserin
