Biomolecules (Jan 2023)

Genetic Predisposition to Neurological Complications in Patients with COVID-19

  • Nikhil Shri Sahajpal,
  • Alex R. Hastie,
  • Maximilian Schieck,
  • Ashis K. Mondal,
  • Marc Felde,
  • Caspar I. van der Made,
  • Janet S. Chou,
  • Adrienne G. Randolph,
  • Thomas Illig,
  • Michael C. Zody,
  • Catherine A. Brownstein,
  • Alan H. Beggs,
  • Alexander Hoischen,
  • Alka Chaubey,
  • Ravindra Kolhe

DOI
https://doi.org/10.3390/biom13010133
Journal volume & issue
Vol. 13, no. 1
p. 133

Abstract

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Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.

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