Late onset of oral chronic GVHD

Abstract

Chronic graft-versus-host disease is the major late complication following allogeneic hematopoietic stem cell transplantation (HSCT), and the major cause for morbidity and loss of quality of life in HSCT long-term survivors. Oral involvement accounts for around 53% - 70% of bone marrow and peripheral blood stem cell recipients, respectively. We report a case of late onset oral chronic GVHD and discuss the role of the oral health care providers in the early diagnosis and management of this disease. Moreover, oral cGVHD development 4 years after transplantation and coincident with withdrawing immunosuppression is most uncommon and shows the importance of tracking the involvement of the oral cavity after allogeneic transplantation.

Keywords

• Graft Rejection
• Mouth Diseases
• Bone Marrow Transplantation