Nature Communications (Jul 2021)
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
- Cristina C. Clement,
- Angelo D’Alessandro,
- Sangeetha Thangaswamy,
- Samantha Chalmers,
- Raquel Furtado,
- Sheila Spada,
- Giada Mondanelli,
- Federica Ianni,
- Sarah Gehrke,
- Marco Gargaro,
- Giorgia Manni,
- Luisa Carlota Lopez Cara,
- Peter Runge,
- Wanxia Li Tsai,
- Sinem Karaman,
- Jorge Arasa,
- Ruben Fernandez-Rodriguez,
- Amanda Beck,
- Antonio Macchiarulo,
- Massimo Gadina,
- Cornelia Halin,
- Francesca Fallarino,
- Mihaela Skobe,
- Marc Veldhoen,
- Simone Moretti,
- Silvia Formenti,
- Sandra Demaria,
- Rajesh K. Soni,
- Roberta Galarini,
- Roccaldo Sardella,
- Gregoire Lauvau,
- Chaim Putterman,
- Kari Alitalo,
- Ursula Grohmann,
- Laura Santambrogio
Affiliations
- Cristina C. Clement
- Department of Radiation Oncology, Weill Cornell Medicine
- Angelo D’Alessandro
- Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus
- Sangeetha Thangaswamy
- Department of Radiation Oncology, Weill Cornell Medicine
- Samantha Chalmers
- Division of Rheumatology and the Department of Microbiology and Immunology, Albert Einstein College of Medicine
- Raquel Furtado
- Division of Rheumatology and the Department of Microbiology and Immunology, Albert Einstein College of Medicine
- Sheila Spada
- Department of Radiation Oncology, Weill Cornell Medicine
- Giada Mondanelli
- Department of Medicine and Surgery, University of Perugia
- Federica Ianni
- Department of Pharmaceutical Sciences, University of Perugia
- Sarah Gehrke
- Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus
- Marco Gargaro
- Department of Medicine and Surgery, University of Perugia
- Giorgia Manni
- Department of Medicine and Surgery, University of Perugia
- Luisa Carlota Lopez Cara
- Department of Pharmaceutical & Organic Chemistry, Faculty of Pharmacy, University of Granada
- Peter Runge
- Institute of Pharmaceutical Sciences, ETH Zurich
- Wanxia Li Tsai
- Translational Immunology Section, National Institute of Arthritis Musculoskeletal and Skin Diseases
- Sinem Karaman
- Wihuri Research Institute and Translational Cancer Medicine Research Program, University of Helsinki
- Jorge Arasa
- Institute of Pharmaceutical Sciences, ETH Zurich
- Ruben Fernandez-Rodriguez
- Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Amanda Beck
- Department of Pathology, Albert Einstein College of Medicine
- Antonio Macchiarulo
- Department of Pharmaceutical Sciences, University of Perugia
- Massimo Gadina
- Translational Immunology Section, National Institute of Arthritis Musculoskeletal and Skin Diseases
- Cornelia Halin
- Institute of Pharmaceutical Sciences, ETH Zurich
- Francesca Fallarino
- Department of Medicine and Surgery, University of Perugia
- Mihaela Skobe
- Department of Oncological Sciences and Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Marc Veldhoen
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa
- Simone Moretti
- Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche “Togo Rosati”
- Silvia Formenti
- Department of Radiation Oncology, Weill Cornell Medicine
- Sandra Demaria
- Department of Radiation Oncology, Weill Cornell Medicine
- Rajesh K. Soni
- Proteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center
- Roberta Galarini
- Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche “Togo Rosati”
- Roccaldo Sardella
- Department of Pharmaceutical Sciences, University of Perugia
- Gregoire Lauvau
- Division of Rheumatology and the Department of Microbiology and Immunology, Albert Einstein College of Medicine
- Chaim Putterman
- Division of Rheumatology and the Department of Microbiology and Immunology, Albert Einstein College of Medicine
- Kari Alitalo
- Wihuri Research Institute and Translational Cancer Medicine Research Program, University of Helsinki
- Ursula Grohmann
- Department of Medicine and Surgery, University of Perugia
- Laura Santambrogio
- Department of Radiation Oncology, Weill Cornell Medicine
- DOI
- https://doi.org/10.1038/s41467-021-24785-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. Here the authors identify 3-HKA as a biogenic amine and show it has anti-inflammatory properties that can protect mice against psoriasis and nephrotoxic nephritis.
