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BMC Biotechnology
(Feb 2019)
Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies
Marie-Claire Devilder,
Melinda Moyon,
Laetitia Gautreau-Rolland,
Benjamin Navet,
Jeanne Perroteau,
Florent Delbos,
Marie-Claude Gesnel,
Richard Breathnach,
Xavier Saulquin
Affiliations
Marie-Claire Devilder
CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes
Melinda Moyon
CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes
Laetitia Gautreau-Rolland
CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes
Benjamin Navet
CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes
Jeanne Perroteau
CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes
Florent Delbos
HLA Laboratory, EFS Centre Pays de la Loire
Marie-Claude Gesnel
CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes
Richard Breathnach
CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes
Xavier Saulquin
CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes
DOI
https://doi.org/10.1186/s12896-019-0504-z
Journal volume & issue
Vol. 19, no. 1
pp. 1 – 13
Abstract
Read online
No abstracts available.
Keywords
Human antibodies
SHM
CRISPR
CRISPR-X
AID
Tetramers
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