Revista do Colégio Brasileiro de Cirurgiões ()

Immunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinoma

  • Leandro Totti Cavazzola,
  • André Ricardo Pereira da Rosa,
  • Carlos Cauduro Schirmer,
  • Richard Ricachenevski Gurski,
  • João Pedro Bueno Telles,
  • Fernando Mielke,
  • Luíse Meurer,
  • Maria Isabel Albano Edelweiss,
  • Cleber Dario Pinto Kruel

DOI
https://doi.org/10.1590/S0100-69912009000100007
Journal volume & issue
Vol. 36, no. 1
pp. 24 – 34

Abstract

Read online

OBJECTIVES: To correlate the expression of p53 protein and VEGF with the prognosis of patients submitted to curative resection to treat esophageal adenocarcinoma. METHODS: Forty-six patients with esophageal adenocarcinoma, submitted to curative resection, were studied. The expressions of p53 protein and VEGF were assessed by immunohistochemistry in 52.2% and 47.8% of tumors, respectively. RESULTS: P53 protein and VEGF expressions coincided in 26% of the cases, and no correlation between these expressions was observed. None of the clinicopathological factors showed a significant correlation with p53 protein or VEGF expressions. There was no significant association between p53 protein and VEGF expressions and long-term survival. CONCLUSION: The expression of p53 protein and VEGF did not correlate with prognosis in esophageal adenocarcinoma patients submitted to curative resection.

Keywords