eLife (Dec 2021)
Building a community to engineer synthetic cells and organelles from the bottom-up
- Oskar Staufer,
- Jacqueline A De Lora,
- Eleonora Bailoni,
- Alisina Bazrafshan,
- Amelie S Benk,
- Kevin Jahnke,
- Zachary A Manzer,
- Lado Otrin,
- Telmo Díez Pérez,
- Judee Sharon,
- Jan Steinkühler,
- Katarzyna P Adamala,
- Bruna Jacobson,
- Marileen Dogterom,
- Kerstin Göpfrich,
- Darko Stefanovic,
- Susan R Atlas,
- Michael Grunze,
- Matthew R Lakin,
- Andrew P Shreve,
- Joachim P Spatz,
- Gabriel P López
Affiliations
- Oskar Staufer
- ORCiD
- Max Planck Institute for Medical Research, Heidelberg, Germany; Max Planck School Matter to Life, Heidelberg, Germany; Max Planck Bristol Center for Minimal Biology, University of Bristol, Bristol, United Kingdom
- Jacqueline A De Lora
- ORCiD
- Max Planck Institute for Medical Research, Heidelberg, Germany
- Eleonora Bailoni
- University of Groningen, Groningen, Netherlands
- Alisina Bazrafshan
- ORCiD
- Emory University, Atlanta, United States
- Amelie S Benk
- Max Planck Institute for Medical Research, Heidelberg, Germany
- Kevin Jahnke
- ORCiD
- Max Planck Institute for Medical Research, Heidelberg, Germany
- Zachary A Manzer
- ORCiD
- Cornell University, Ithaca, United States
- Lado Otrin
- ORCiD
- Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany
- Telmo Díez Pérez
- University of New Mexico, Albuquerque, United States
- Judee Sharon
- ORCiD
- University of Minnesota, Minneapolis, United States
- Jan Steinkühler
- ORCiD
- Northwestern University, Evanston, United States
- Katarzyna P Adamala
- ORCiD
- University of Minnesota, Minneapolis, United States
- Bruna Jacobson
- University of New Mexico, Albuquerque, United States
- Marileen Dogterom
- ORCiD
- BaSyC Consortium, Delft, Netherlands
- Kerstin Göpfrich
- ORCiD
- Max Planck Institute for Medical Research, Heidelberg, Germany; Max Planck School Matter to Life, Heidelberg, Germany
- Darko Stefanovic
- University of New Mexico, Albuquerque, United States
- Susan R Atlas
- ORCiD
- University of New Mexico, Albuquerque, United States
- Michael Grunze
- ORCiD
- Max Planck Institute for Medical Research, Heidelberg, Germany; Max Planck School Matter to Life, Heidelberg, Germany
- Matthew R Lakin
- University of New Mexico, Albuquerque, United States
- Andrew P Shreve
- ORCiD
- University of New Mexico, Albuquerque, United States
- Joachim P Spatz
- ORCiD
- Max Planck Institute for Medical Research, Heidelberg, Germany; Max Planck School Matter to Life, Heidelberg, Germany; Max Planck Bristol Center for Minimal Biology, University of Bristol, Bristol, United Kingdom
- Gabriel P López
- ORCiD
- University of New Mexico, Albuquerque, United States
- DOI
- https://doi.org/10.7554/eLife.73556
- Journal volume & issue
-
Vol. 10
Abstract
Employing concepts from physics, chemistry and bioengineering, 'learning-by-building' approaches are becoming increasingly popular in the life sciences, especially with researchers who are attempting to engineer cellular life from scratch. The SynCell2020/21 conference brought together researchers from different disciplines to highlight progress in this field, including areas where synthetic cells are having socioeconomic and technological impact. Conference participants also identified the challenges involved in designing, manipulating and creating synthetic cells with hierarchical organization and function. A key conclusion is the need to build an international and interdisciplinary research community through enhanced communication, resource-sharing, and educational initiatives.
Keywords
