Nature Communications (Aug 2016)
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
- Chia-Wei Li,
- Seung-Oe Lim,
- Weiya Xia,
- Heng-Huan Lee,
- Li-Chuan Chan,
- Chu-Wei Kuo,
- Kay-Hooi Khoo,
- Shih-Shin Chang,
- Jong-Ho Cha,
- Taewan Kim,
- Jennifer L. Hsu,
- Yun Wu,
- Jung-Mao Hsu,
- Hirohito Yamaguchi,
- Qingqing Ding,
- Yan Wang,
- Jun Yao,
- Cheng-Chung Lee,
- Hsing-Ju Wu,
- Aysegul A. Sahin,
- James P. Allison,
- Dihua Yu,
- Gabriel N. Hortobagyi,
- Mien-Chie Hung
Affiliations
- Chia-Wei Li
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Seung-Oe Lim
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Weiya Xia
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Heng-Huan Lee
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Li-Chuan Chan
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Chu-Wei Kuo
- Core Facilities for Protein Structural Analysis, Academia Sinica
- Kay-Hooi Khoo
- Institute of Biological Chemistry, Academia Sinica
- Shih-Shin Chang
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Jong-Ho Cha
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Taewan Kim
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Jennifer L. Hsu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Yun Wu
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Jung-Mao Hsu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Hirohito Yamaguchi
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Qingqing Ding
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Yan Wang
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Jun Yao
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Cheng-Chung Lee
- Core Facilities for Protein Structural Analysis, Academia Sinica
- Hsing-Ju Wu
- Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University
- Aysegul A. Sahin
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- James P. Allison
- Department of Immunology, The University of Texas MD Anderson Cancer Center
- Dihua Yu
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Gabriel N. Hortobagyi
- Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center
- Mien-Chie Hung
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/ncomms12632
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 11
Abstract
Programmed Death ligand-1 (PD-L1) protein mediates immune suppression in cancer. Here, the authors show that in breast cancer, PD-L1 expression can be up regulated post-translationally by glycosylation, which in turn acts through inhibiting GSK3β-mediated PD-L1 degradation.
