Nature Communications (Feb 2023)

On-demand male contraception via acute inhibition of soluble adenylyl cyclase

  • Melanie Balbach,
  • Thomas Rossetti,
  • Jacob Ferreira,
  • Lubna Ghanem,
  • Carla Ritagliati,
  • Robert W. Myers,
  • David J. Huggins,
  • Clemens Steegborn,
  • Ileana C. Miranda,
  • Peter T. Meinke,
  • Jochen Buck,
  • Lonny R. Levin

DOI
https://doi.org/10.1038/s41467-023-36119-6
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 12

Abstract

Read online

Half of all pregnancies are unintended; thus, existing family planning options are inadequate. This proof-of-concept study validates an on-demand contraception strategy for men, showing high effectiveness in quickly and temporarily reducing male fertility in mice.