Nature Communications (Feb 2017)
Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
- Juan R. Hernandez-Fernaud,
- Elena Ruengeler,
- Andrea Casazza,
- Lisa J. Neilson,
- Ellie Pulleine,
- Alice Santi,
- Shehab Ismail,
- Sergio Lilla,
- Sandeep Dhayade,
- Iain R. MacPherson,
- Iain McNeish,
- Darren Ennis,
- Hala Ali,
- Fernanda G. Kugeratski,
- Heba Al Khamici,
- Maartje van den Biggelaar,
- Peter V.E. van den Berghe,
- Catherine Cloix,
- Laura McDonald,
- David Millan,
- Aoisha Hoyle,
- Anna Kuchnio,
- Peter Carmeliet,
- Stella M. Valenzuela,
- Karen Blyth,
- Huabing Yin,
- Massimiliano Mazzone,
- Jim C. Norman,
- Sara Zanivan
Affiliations
- Juan R. Hernandez-Fernaud
- Cancer Research UK Beatson Institute
- Elena Ruengeler
- Cancer Research UK Beatson Institute
- Andrea Casazza
- Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
- Lisa J. Neilson
- Cancer Research UK Beatson Institute
- Ellie Pulleine
- Division of Biomedical Engineering, School of Engineering, University of Glasgow
- Alice Santi
- Cancer Research UK Beatson Institute
- Shehab Ismail
- Cancer Research UK Beatson Institute
- Sergio Lilla
- Cancer Research UK Beatson Institute
- Sandeep Dhayade
- Cancer Research UK Beatson Institute
- Iain R. MacPherson
- Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow
- Iain McNeish
- Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow
- Darren Ennis
- Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow
- Hala Ali
- School of Life Sciences, University of Technology Sydney
- Fernanda G. Kugeratski
- Cancer Research UK Beatson Institute
- Heba Al Khamici
- School of Life Sciences, University of Technology Sydney
- Maartje van den Biggelaar
- Department of Plasma Proteins, Sanquin Research
- Peter V.E. van den Berghe
- Cancer Research UK Beatson Institute
- Catherine Cloix
- Cancer Research UK Beatson Institute
- Laura McDonald
- Cancer Research UK Beatson Institute
- David Millan
- Department of Pathology, Queen Elizabeth University Hospital
- Aoisha Hoyle
- Department of Pathology, Queen Elizabeth University Hospital
- Anna Kuchnio
- Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, Vesalius Research Center, VIB
- Peter Carmeliet
- Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, Vesalius Research Center, VIB
- Stella M. Valenzuela
- School of Life Sciences, University of Technology Sydney
- Karen Blyth
- Cancer Research UK Beatson Institute
- Huabing Yin
- Division of Biomedical Engineering, School of Engineering, University of Glasgow
- Massimiliano Mazzone
- Laboratory of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB
- Jim C. Norman
- Cancer Research UK Beatson Institute
- Sara Zanivan
- Cancer Research UK Beatson Institute
- DOI
- https://doi.org/10.1038/ncomms14206
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
The secretome from cancer and stromal cells contributes to the creation of a microenvironment, which in turn contributes to invasion and angiogenesis. Here, the authors compare the secretomes of immortalized normal fibroblasts and cancer-derived fibroblast and identify CLIC3 as a driver of cancer progression.
