Hygiene and Environmental Health Advances (Dec 2024)
A prospective study on the cardiorespiratory effects of air pollution among residents of the Tibetan Plateau
- Xin Meng,
- Qiaoyi Hua,
- Ruiwei Xu,
- Yunxiu Shi,
- Yi Zhang,
- Meilin Yan,
- Wu Chen,
- Yifan Xu,
- Yunfei Fan,
- Yuan Yao,
- Teng Wang,
- Yidan Zhang,
- Haonan Li,
- Yaqi Yu,
- Xiaoyu Cui,
- Qianqian Chai,
- Ailin Li,
- Mengshuang Sheng,
- Rui Tang,
- Ruohong Qiao,
- Jiangjianghui Li,
- Buduo,
- Danzengdunzhu,
- Zhuoga,
- Lei Hou,
- Yingjun Liu,
- Jing Shang,
- Qi Chen,
- Xinghua Qiu,
- Jicheng Gong,
- Tong Zhu
Affiliations
- Xin Meng
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Qiaoyi Hua
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Ruiwei Xu
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Yunxiu Shi
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Yi Zhang
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Meilin Yan
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China; Department of Environmental Science and Engineering, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, PR China
- Wu Chen
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Yifan Xu
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Yunfei Fan
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China; China National Environmental Monitoring Centre, Beijing 100012, PR China
- Yuan Yao
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Teng Wang
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Yidan Zhang
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Haonan Li
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Yaqi Yu
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China; School of Environmental Science and Engineering, Qingdao University, Qingdao 266071, PR China
- Xiaoyu Cui
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Qianqian Chai
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Ailin Li
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Mengshuang Sheng
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Rui Tang
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Ruohong Qiao
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Jiangjianghui Li
- Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health and Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100083, PR China
- Buduo
- College of Science, Tibet University, Lhasa, Tibet Autonomous Region, 850011, PR China
- Danzengdunzhu
- College of Medicine, Tibet University, Lhasa, Tibet Autonomous Region, 850011, PR China
- Zhuoga
- Clinical Laboratory, the Second People's Hospital of Tibet Autonomous Region, Lhasa, Tibet Autonomous Region 850000, PR China
- Lei Hou
- College of Resources and Environment, Tibet Agricultural and Animal Husbandry University, Nyingchi, Tibet Autonomous Region 860000, PR China
- Yingjun Liu
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Jing Shang
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Qi Chen
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Xinghua Qiu
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China
- Jicheng Gong
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China; Corresponding authors.
- Tong Zhu
- SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, and Center for Environment and Health, Peking University, Beijing 100871, PR China; Corresponding authors.
- Journal volume & issue
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Vol. 12
p. 100115
Abstract
The Tibetan Plateau is characterized by high ozone concentration which poses a significant public health concern. However, the causal evidence linking ozone pollution to adverse cardiopulmonary health impacts, as well as the understanding of its underlying biological mechanisms, remains limited. Additionally, exposure levels to particulate and other gaseous air pollutants along with their associated health effects in this region are largely unknown. To address these gaps, we conducted a prospective follow-up study in Tibet from May 2021 to November 2021. In consideration of the potential synergistic effects of chronic hypobaric hypoxia, two Tibetan cities with different altitudes, Lhasa (3650 m) and Nyingchi (3000 m), were chosen to implement atmospheric monitoring and health measurement. We employed cutting-edge, high-precision instruments at stationary monitoring sites to measure ambient air pollution and collected particle samples. Portable devices were used to monitor personal exposure levels of ozone and black carbon. A total of 212 healthy Tibetan college students participated in up to four clinical visits, yielding 774 visits in total, during which functional endpoints were measured and biological samples were collected. The primary aim of this study is to evaluate the cardiorespiratory effects of ambient ozone under hypoxic conditions, where its impact may be amplified due to the region's unique environmental characteristics. The secondary aim is to provide a comprehensive assessment of other air pollutants, including their exposure levels, sources, and health effects. By addressing these aims, the study offers valuable insights into air quality and its health implications in this unique high-altitude setting. This paper outlines the research motivation, measurement framework, and preliminary findings.
