Nature Communications (Sep 2020)
Cryo-EM structure of the varicella-zoster virus A-capsid
- Junqing Sun,
- Congcong Liu,
- Ruchao Peng,
- Fu-Kun Zhang,
- Zhou Tong,
- Sheng Liu,
- Yi Shi,
- Zhennan Zhao,
- Wen-Bo Zeng,
- George Fu Gao,
- Hong-Jie Shen,
- Xiaoming Yang,
- Minhua Luo,
- Jianxun Qi,
- Peiyi Wang
Affiliations
- Junqing Sun
- Shanxi Academy of Advanced Research and Innovation
- Congcong Liu
- Cryo-EM Centre, Southern University of Science and Technology
- Ruchao Peng
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS)
- Fu-Kun Zhang
- Changchun Keygen Biological Products Co. Ltd.
- Zhou Tong
- Shanxi Academy of Advanced Research and Innovation
- Sheng Liu
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS)
- Yi Shi
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS)
- Zhennan Zhao
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS)
- Wen-Bo Zeng
- State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences
- George Fu Gao
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS)
- Hong-Jie Shen
- Changchun Keygen Biological Products Co. Ltd.
- Xiaoming Yang
- China National Pharmaceutical Group Corporation
- Minhua Luo
- University of Chinese Academy of Sciences
- Jianxun Qi
- CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS)
- Peiyi Wang
- Cryo-EM Centre, Southern University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-020-18537-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Varicella-zoster virus (VZV) is the causative agent of chickenpox and herpes zoster (shingles). Cryo-EM structure of VZV capsid provides insights into the capsid assembly and reveals a pocket that could potentially be targeted by antiviral drugs.
