Nature Communications (Apr 2022)
PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration
- Wenji Piao,
- Lushen Li,
- Vikas Saxena,
- Jegan Iyyathurai,
- Ram Lakhan,
- Yigang Zhang,
- Isadora Tadeval Lape,
- Christina Paluskievicz,
- Keli L. Hippen,
- Young Lee,
- Emma Silverman,
- Marina W. Shirkey,
- Leonardo V. Riella,
- Bruce R. Blazar,
- Jonathan S. Bromberg
Affiliations
- Wenji Piao
- Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
- Lushen Li
- Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
- Vikas Saxena
- Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
- Jegan Iyyathurai
- Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
- Ram Lakhan
- Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
- Yigang Zhang
- Division of Blood & Marrow Transplant & Cellular Therapy, Department of Pediatrics, University of Minnesota Cancer Center
- Isadora Tadeval Lape
- Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts
- Christina Paluskievicz
- Department of Surgery, University of Maryland School of Medicine
- Keli L. Hippen
- Division of Blood & Marrow Transplant & Cellular Therapy, Department of Pediatrics, University of Minnesota Cancer Center
- Young Lee
- Department of Surgery, University of Maryland School of Medicine
- Emma Silverman
- Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
- Marina W. Shirkey
- Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
- Leonardo V. Riella
- Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts
- Bruce R. Blazar
- Division of Blood & Marrow Transplant & Cellular Therapy, Department of Pediatrics, University of Minnesota Cancer Center
- Jonathan S. Bromberg
- Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-29930-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The Programmed death-1 (PD-1) and its ligand PD-L1 are critical checkpoints in the regulation of immune responses. Here the authors implicate PD-L1 signalling at lymphatic endothelium in the regulation of transendothelial migration of T cells.
