فصلنامه دانشگاه علوم پزشکی جهرم (Apr 2015)
Effect of hydro- alcoholic extract of Heracleum persicum during pregnancy on liver enzymes (AST-ALT-ALP) and biochemical factors(Albumin and protein) of infant male rats.
Abstract
Introduction: Liver is one of the vital organs which has a key role in regulating most physiologic mechanisms. In this research the effects of hydro alcoholic extract of Heraclum persicum, on liver enzymes and blood biochemical factors of male infant rats during pregnancy is investigated. Material and methods: In the emperimental study 40 Wistar male newborn rats were divided into 5 groups of 8, their mothers were divided into 5 groups of 8 too, namely control, sham and 3 experimental . Control group didn’t receive any things, sham group received only distilled water. The experimental groups received 100,200,400 (mg/kg) Heracleum persicum respectively for a period of 21 days (during period of pregnancy). At the end of pregnancy,and 25 days of infancy period blood samples were taken from all subjects and liver enzymes ALT,AST ,ALP also Albumin and total protein were determined by Autoanalyzer in order to evaluate the liver function. Analysed using ANOVA and Tukey tes. Result: levels of AST and ALT enzymes in the experimental group 2 and 3 that received the extracts with 200 and 400 mg/kg dose showed statistically significant increase compared with control and sham groups (p<0/05).level of albumin showed significant increase in the experimental group with 400 mg/kg in comparison with control and sham groups (p<0/05). The serum levels of ALP and total protein did not change significantly in experimental group compared to control and sham groups. Conclusions: The Hydro-Alcohlic extract of Heracleum persicum probably has a significant effect on Change in liver function.This effect may be due to the presence of furanocoumarins and trans-anethole in the extract .this effect is reflected in the increase of ALT and AST also alkaloids and flavonoids it can be attribnted to the increase in the hepatic serum level of the albumin.
