Journal of Medical Case Reports (Sep 2019)

Focal segmental glomerulosclerosis in which urinary protein improved after surgical treatment for acromegaly: a case report

  • Arina Yamasaki,
  • Daisuke Bito,
  • Erina Eto,
  • Keiichiro Matsumoto,
  • Megumi Nakamura,
  • Junji Miyazaki,
  • Kenichi Matsumoto,
  • Masanori Masuda,
  • Daisuke Mori,
  • Toru Yoshimura

DOI
https://doi.org/10.1186/s13256-019-2228-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 6

Abstract

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Abstract Background Focal segmental glomerulosclerosis is characterized by partial (segmental) sclerotic lesions in some glomeruli (focal). Primary focal segmental glomerulosclerosis is generally considered resistant to steroid therapy. However, acromegaly is a disease that causes peculiar facial features, body types, and metabolic abnormalities due to the excessive secretion of growth hormone by a pituitary adenoma. Growth hormone has been reported to be involved in glomerular cell growth, mesangial proliferation, and glomerulosclerosis in the kidney. Case presentation We report a case of a Japanese patient with focal segmental glomerulosclerosis in whom decreased urinary protein was observed after surgical treatment for acromegaly. Conclusion The patient’s urinary protein improved as the concentration of growth hormone/insulin-like growth factor 1 decreased.

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