Anandins A and B, Two Rare Steroidal Alkaloids from a Marine Streptomyces anandii H41-59

Abstract

Anandins A (1) and B (2), two rare steroidal alkaloids, were isolated from the fermentative broth of a marine actinobacteria Streptomyces anandii H41-59. The gross structures of the two alkaloids were elucidated by spectroscopic methods including HR-ESI-MS, and NMR. Their absolute configurations were confirmed by single-crystal X-ray diffraction analysis and comparison of their experimental and calculated electronic circular dichroism spectra, respectively. Anandin A exhibited a moderate inhibitory effect against three human cancer cell lines MCF-7, SF-268, and NCI-H460 with IC50 values of 7.5, 7.9, 7.8 μg/mL, respectively.

Keywords

• Streptomyces anandii
• anandins A and B
• steroidal alkaloids
• cytotoxicity