Communications Biology (Oct 2022)

First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria

  • Yamato Takeuchi,
  • Kazunori Ushimaru,
  • Kohei Kaneda,
  • Chitose Maruyama,
  • Takashi Ito,
  • Kazuya Yamanaka,
  • Yasushi Ogasawara,
  • Hajime Katano,
  • Yasuo Kato,
  • Tohru Dairi,
  • Yoshimitsu Hamano

DOI
https://doi.org/10.1038/s42003-022-04110-4
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 14

Abstract

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Bacteria-derived polycationic homopoly(amino acid)s are reported for the first time to directly penetrate cell membrane and deliver proteins of interest into cells, representing a new type of cell penetrating peptides for intracellular delivery.