NO metabolism and lipid peroxidation intensity in young individuals with normal, optimal normal, and high normal blood pressure

Abstract

Metabolism of NO, an endogenous vasodilatator, and lipid peroxidation intensity were analyzed in young subjects with normal blood pressure (BP) (<140 mm Hg). In total, 84 male patients aged 18-45years were examined: 32 subjects with optimal normal BP, and 52 - with high normal BP. Comparing to individuals with normal/optimal BP, participants with high normal BP demonstrated increased BP variability and NO synthesis, intensified lipid peroxidation and reduced plasma antioxidant activity (AOA). In high normal BP individuals, higher BP correlated with enhanced NO production, but in longterm BP increase, NO level tended to be reduced. The higher lipid peroxidation intensity was, the lower AOA was registered. In every fourth patient with high normal BP, some abnormalities in vasomotor regulation of vascular tonus were observed.

Keywords

• optimal blood pressure
• high normal blood pressure
• bp variability
• no
• lipid peroxidation intensity