eLife (Jul 2019)
Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age
- Simone Kühn,
- Anna Mascharek,
- Tobias Banaschewski,
- Arun Bodke,
- Uli Bromberg,
- Christian Büchel,
- Erin Burke Quinlan,
- Sylvane Desrivieres,
- Herta Flor,
- Antoine Grigis,
- Hugh Garavan,
- Penny A Gowland,
- Andreas Heinz,
- Bernd Ittermann,
- Jean-Luc Martinot,
- Frauke Nees,
- Dimitri Papadopoulos Orfanos,
- Tomas Paus,
- Luise Poustka,
- Sabina Millenet,
- Juliane H Fröhner,
- Michael N Smolka,
- Henrik Walter,
- Robert Whelan,
- Gunter Schumann,
- Ulman Lindenberger,
- Jürgen Gallinat,
- IMAGEN Consortium
Affiliations
- Simone Kühn
- ORCiD
- Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
- Anna Mascharek
- ORCiD
- Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Tobias Banaschewski
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Arun Bodke
- Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
- Uli Bromberg
- University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
- Christian Büchel
- ORCiD
- University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
- Erin Burke Quinlan
- Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom
- Sylvane Desrivieres
- Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom
- Herta Flor
- Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany
- Antoine Grigis
- NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France
- Hugh Garavan
- Department of Psychiatry, University of Vermont, Burlington, United States; Department of Psychology, University of Vermont, Burlington, United States
- Penny A Gowland
- Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom
- Andreas Heinz
- Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Berlin, Germany
- Bernd Ittermann
- Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany
- Jean-Luc Martinot
- Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 “Neuroimaging & Psychiatry”, University ParisSud, University Paris Descartes, Paris, France
- Frauke Nees
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany
- Dimitri Papadopoulos Orfanos
- ORCiD
- NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France
- Tomas Paus
- Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada; Department of Psychology, University of Toronto, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada
- Luise Poustka
- Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany
- Sabina Millenet
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- Juliane H Fröhner
- Neuroimaging Center,Department of Psychiatry, Technische Universität Dresden, Dresden, Germany
- Michael N Smolka
- Neuroimaging Center,Department of Psychiatry, Technische Universität Dresden, Dresden, Germany
- Henrik Walter
- Department of Psychiatry and Psychotherapy, Charité – Universitätsmedizin Berlin, Berlin, Germany
- Robert Whelan
- Global Brain Health Institute,School of Psychology, Trinity College Dublin, Dublin, Ireland
- Gunter Schumann
- Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom
- Ulman Lindenberger
- ORCiD
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany
- Jürgen Gallinat
- Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- IMAGEN Consortium
- DOI
- https://doi.org/10.7554/eLife.44056
- Journal volume & issue
-
Vol. 8
Abstract
Adolescence is a common time for initiation of alcohol use and development of alcohol use disorders. The present study investigates neuroanatomical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain structural equation modeling framework. In 1814 healthy adolescents of the IMAGEN sample, the Alcohol Use Disorder Identification Test (AUDIT) was acquired at three measurement occasions across five years. Based on a two-part latent growth curve model, we conducted whole-brain analyses on structural MRI data at age 14, predicting change in alcohol use score over time. Higher grey-matter volumes in the caudate nucleus and the left cerebellum at age 14 years were predictive of stronger increase in alcohol use score over 5 years. The study is the first to demonstrate the feasibility of running separate voxel-wise structural equation models thereby opening new avenues for data analysis in brain imaging.
Keywords
- alcohol use
- adolescence
- structural equation modelling, latent growth curve modelling
- brain structure
