Nature Communications (Feb 2023)
Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus
- Chachrit Khunsriraksakul,
- Qinmengge Li,
- Havell Markus,
- Matthew T. Patrick,
- Renan Sauteraud,
- Daniel McGuire,
- Xingyan Wang,
- Chen Wang,
- Lida Wang,
- Siyuan Chen,
- Ganesh Shenoy,
- Bingshan Li,
- Xue Zhong,
- Nancy J. Olsen,
- Laura Carrel,
- Lam C. Tsoi,
- Bibo Jiang,
- Dajiang J. Liu
Affiliations
- Chachrit Khunsriraksakul
- Program in Bioinformatics and Genomics, Pennsylvania State University College of Medicine
- Qinmengge Li
- Department of Dermatology, University of Michigan Medical School
- Havell Markus
- Program in Bioinformatics and Genomics, Pennsylvania State University College of Medicine
- Matthew T. Patrick
- Department of Dermatology, University of Michigan Medical School
- Renan Sauteraud
- Department of Public Health Sciences, Pennsylvania State University College of Medicine
- Daniel McGuire
- Department of Public Health Sciences, Pennsylvania State University College of Medicine
- Xingyan Wang
- Department of Public Health Sciences, Pennsylvania State University College of Medicine
- Chen Wang
- Program in Bioinformatics and Genomics, Pennsylvania State University College of Medicine
- Lida Wang
- Department of Public Health Sciences, Pennsylvania State University College of Medicine
- Siyuan Chen
- Department of Public Health Sciences, Pennsylvania State University College of Medicine
- Ganesh Shenoy
- Department of Neurosurgery, Pennsylvania State University College of Medicine
- Bingshan Li
- Department of Molecular Physiology & Biophysics, Vanderbilt University
- Xue Zhong
- Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center
- Nancy J. Olsen
- Department of Medicine, Pennsylvania State University College of Medicine
- Laura Carrel
- Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine
- Lam C. Tsoi
- Department of Dermatology, University of Michigan Medical School
- Bibo Jiang
- Department of Public Health Sciences, Pennsylvania State University College of Medicine
- Dajiang J. Liu
- Program in Bioinformatics and Genomics, Pennsylvania State University College of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36306-5
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
The genetic basis of systemic lupus erythematosus is not completely understood. Here, the authors perform multi-ancestry and multi-trait meta-analyses to identify 16 novel genetic loci and demonstrate the utility of polygenic risk score in clinical risk prediction when used with conventional lab tests.
