Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing

Michele Veldsman; Xin-You Tai; Thomas Nichols; Steve Smith; João Peixoto; Sanjay Manohar; Masud Husain

doi:10.1038/s41467-020-18201-5

Nature Communications (Sep 2020)

Cerebrovascular risk factors impact frontoparietal network integrity and executive function in healthy ageing

Michele Veldsman,
Xin-You Tai,
Thomas Nichols,
Steve Smith,
João Peixoto,
Sanjay Manohar,
Masud Husain

Affiliations

Michele Veldsman: Wellcome Centre for Integrative Neuroimaging, University of Oxford
Xin-You Tai: Nuffield Department of Clinical Neuroscience, University of Oxford
Thomas Nichols: Nuffield Department of Population Health, University of Oxford
Steve Smith: Wellcome Centre for Integrative Neuroimaging, University of Oxford
João Peixoto: Department of Experimental Psychology, University of Oxford
Sanjay Manohar: Department of Experimental Psychology, University of Oxford
Masud Husain: Wellcome Centre for Integrative Neuroimaging, University of Oxford

DOI: https://doi.org/10.1038/s41467-020-18201-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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Cerebrovascular risk factors reduce cognitive performance via changes in the integrity of a frontoparietal brain network in ageing. Modification of blood pressure, with antihypertensive treatment in mid-life, mitigates against cognitive decline over a specific blood pressure range.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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