Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH)

Xinzhi Li; Kaixin Ding; Xueying Li; Bingchuan Yuan; Yuqin Wang; Zhicheng Yao; Shuaikang Wang; He Huang; Bolin Xu; Liwei Xie; Tuo Deng; Xiao-wei Chen; Zheng Chen

doi:10.1038/s41467-022-32163-w

Nature Communications (Aug 2022)

Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH)

Xinzhi Li,
Kaixin Ding,
Xueying Li,
Bingchuan Yuan,
Yuqin Wang,
Zhicheng Yao,
Shuaikang Wang,
He Huang,
Bolin Xu,
Liwei Xie,
Tuo Deng,
Xiao-wei Chen,
Zheng Chen

Affiliations

Xinzhi Li: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Kaixin Ding: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Xueying Li: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Bingchuan Yuan: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Yuqin Wang: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology
Zhicheng Yao: Department of General Surgery, The Third Affiliated Hospital of Sun Yat-sen University
Shuaikang Wang: Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University
He Huang: Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University
Bolin Xu: State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, and Center for Life Sciences, Peking University
Liwei Xie: Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences
Tuo Deng: National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University
Xiao-wei Chen: State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, College of Future Technology, and Center for Life Sciences, Peking University
Zheng Chen: HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology

DOI: https://doi.org/10.1038/s41467-022-32163-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Ectopic lipid accumulation and inflammation are the essential signs of NASH. Here, the authors show that hepatic WTAP is a key integrative repressor of ectopic lipid accumulation and inflammation during NASH progression, and hepatic deletion of Wtap promotes both of them, leading to NASH

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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