Scientific Reports (May 2018)
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21
- Quinn T. Ostrom,
- Ben Kinnersley,
- Margaret R. Wrensch,
- Jeanette E. Eckel-Passow,
- Georgina Armstrong,
- Terri Rice,
- Yanwen Chen,
- John K. Wiencke,
- Lucie S. McCoy,
- Helen M. Hansen,
- Christopher I. Amos,
- Jonine L. Bernstein,
- Elizabeth B. Claus,
- Dora Il’yasova,
- Christoffer Johansen,
- Daniel H. Lachance,
- Rose K. Lai,
- Ryan T. Merrell,
- Sara H. Olson,
- Siegal Sadetzki,
- Joellen M. Schildkraut,
- Sanjay Shete,
- Joshua B. Rubin,
- Justin D. Lathia,
- Michael E. Berens,
- Ulrika Andersson,
- Preetha Rajaraman,
- Stephen J. Chanock,
- Martha S. Linet,
- Zhaoming Wang,
- Meredith Yeager,
- GliomaScan consortium,
- Richard S. Houlston,
- Robert B. Jenkins,
- Beatrice Melin,
- Melissa L. Bondy,
- Jill. S. Barnholtz-Sloan
Affiliations
- Quinn T. Ostrom
- Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Ben Kinnersley
- Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton
- Margaret R. Wrensch
- Department of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco
- Jeanette E. Eckel-Passow
- Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine
- Georgina Armstrong
- Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Terri Rice
- Department of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco
- Yanwen Chen
- Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland
- John K. Wiencke
- Department of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco
- Lucie S. McCoy
- Department of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco
- Helen M. Hansen
- Department of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco
- Christopher I. Amos
- Institute for Clinical and Translational Research, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Jonine L. Bernstein
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York
- Elizabeth B. Claus
- School of Public Health, Yale University
- Dora Il’yasova
- Department of Epidemiology and Biostatistics, School of Public Health, Georgia State University
- Christoffer Johansen
- Oncology clinic, Finsen Center, Rigshospitalet
- Daniel H. Lachance
- Department of Neurology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic
- Rose K. Lai
- Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles
- Ryan T. Merrell
- Department of Neurology, NorthShore University HealthSystem
- Sara H. Olson
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York
- Siegal Sadetzki
- Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center
- Joellen M. Schildkraut
- Department of Public Health Sciences, University of Virginia School of Medicine
- Sanjay Shete
- Department of Biostatistics, University of Texas MD Anderson Cancer Center
- Joshua B. Rubin
- Department of Pediatrics, Washington University School of Medicine
- Justin D. Lathia
- Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Foundation, Cleveland
- Michael E. Berens
- Cancer and Cell Biology Division, The Translational Genomics Research Institute
- Ulrika Andersson
- Department of Radiation Sciences, Faculty of Medicine, Umeå University
- Preetha Rajaraman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Martha S. Linet
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Zhaoming Wang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Meredith Yeager
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- GliomaScan consortium
- Richard S. Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton
- Robert B. Jenkins
- Department of Laboratory Medicine and Pathology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic
- Beatrice Melin
- Department of Radiation Sciences, Faculty of Medicine, Umeå University
- Melissa L. Bondy
- Department of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine
- Jill. S. Barnholtz-Sloan
- Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland
- DOI
- https://doi.org/10.1038/s41598-018-24580-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Abstract Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous glioma genome-wide association studies (GWAS) have not stratified by sex. Potential sex-specific genetic effects were assessed in autosomal SNPs and sex chromosome variants for all glioma, GBM and non-GBM patients using data from four previous glioma GWAS. Datasets were analyzed using sex-stratified logistic regression models and combined using meta-analysis. There were 4,831 male cases, 5,216 male controls, 3,206 female cases and 5,470 female controls. A significant association was detected at rs11979158 (7p11.2) in males only. Association at rs55705857 (8q24.21) was stronger in females than in males. A large region on 3p21.31 was identified with significant association in females only. The identified differences in effect of risk variants do not fully explain the observed incidence difference in glioma by sex.
