Molecular Cancer (Nov 2020)
Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer
- Wanjun Gu,
- Junchao Shi,
- Hui Liu,
- Xudong Zhang,
- Jin J. Zhou,
- Musheng Li,
- Dandan Zhou,
- Rui Li,
- Jingzhu Lv,
- Guoxia Wen,
- Shanshan Zhu,
- Ting Qi,
- Wei Li,
- Xiaojing Wang,
- Zhaohua Wang,
- Hua Zhu,
- Changcheng Zhou,
- Kenneth S. Knox,
- Ting Wang,
- Qi Chen,
- Zhongqing Qian,
- Tong Zhou
Affiliations
- Wanjun Gu
- State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University
- Junchao Shi
- Division of Biomedical Sciences, School of Medicine, University of California, Riverside
- Hui Liu
- Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Department of Laboratory Medicine, Bengbu Medical College
- Xudong Zhang
- Division of Biomedical Sciences, School of Medicine, University of California, Riverside
- Jin J. Zhou
- Department of Epidemiology and Biostatistics, University of Arizona
- Musheng Li
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- Dandan Zhou
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- Rui Li
- Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Department of Laboratory Medicine, Bengbu Medical College
- Jingzhu Lv
- Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Department of Laboratory Medicine, Bengbu Medical College
- Guoxia Wen
- State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University
- Shanshan Zhu
- State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University
- Ting Qi
- State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University
- Wei Li
- Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease, Department of Respiration, First Affiliated Hospital, Bengbu Medical College
- Xiaojing Wang
- Anhui Clinical and Preclinical Key Laboratory of Respiratory Disease, Department of Respiration, First Affiliated Hospital, Bengbu Medical College
- Zhaohua Wang
- The Infectious Disease Hospital of Bengbu City
- Hua Zhu
- Department of Surgery, The Ohio State University
- Changcheng Zhou
- Division of Biomedical Sciences, School of Medicine, University of California, Riverside
- Kenneth S. Knox
- Department of Internal Medicine, College of Medicine Phoenix, University of Arizona
- Ting Wang
- Department of Internal Medicine, College of Medicine Phoenix, University of Arizona
- Qi Chen
- Division of Biomedical Sciences, School of Medicine, University of California, Riverside
- Zhongqing Qian
- Anhui Province Key Laboratory of Immunology in Chronic Diseases, Anhui Key Laboratory of Infection and Immunity, Department of Laboratory Medicine, Bengbu Medical College
- Tong Zhou
- Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine
- DOI
- https://doi.org/10.1186/s12943-020-01280-9
- Journal volume & issue
-
Vol. 19,
no. 1
pp. 1 – 6
Abstract
Abstract One unmet challenge in lung cancer diagnosis is to accurately differentiate lung cancer from other lung diseases with similar clinical symptoms and radiological features, such as pulmonary tuberculosis (TB). To identify reliable biomarkers for lung cancer screening, we leverage the recently discovered non-canonical small non-coding RNAs (i.e., tRNA-derived small RNAs [tsRNAs], rRNA-derived small RNAs [rsRNAs], and YRNA-derived small RNAs [ysRNAs]) in human peripheral blood mononuclear cells and develop a molecular signature composed of distinct ts/rs/ysRNAs (TRY-RNA). Our TRY-RNA signature precisely discriminates between control, lung cancer, and pulmonary TB subjects in both the discovery and validation cohorts and outperforms microRNA-based biomarkers, which bears the diagnostic potential for lung cancer screening.
Keywords
