BMC Cardiovascular Disorders (Jan 2019)
Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study
- Sabine Westphal,
- Christian Stoppe,
- Matthias Gruenewald,
- Berthold Bein,
- Jochen Renner,
- Jochen Cremer,
- Mark Coburn,
- Gereon Schaelte,
- Andreas Boening,
- Bernd Niemann,
- Frank Kletzin,
- Jan Roesner,
- Ulrich Strouhal,
- Christian Reyher,
- Rita Laufenberg-Feldmann,
- Marion Ferner,
- Ivo F. Brandes,
- Martin Bauer,
- Andreas Kortgen,
- Sebastian N. Stehr,
- Maria Wittmann,
- Georg Baumgarten,
- Rafael Struck,
- Tanja Meyer-Treschan,
- Peter Kienbaum,
- Matthias Heringlake,
- Julika Schoen,
- Michael Sander,
- Sascha Treskatsch,
- Thorsten Smul,
- Ewa Wolwender,
- Thomas Schilling,
- Frauke Degenhardt,
- Andre Franke,
- Soeren Mucha,
- Lukas Tittmann,
- Madeline Kohlhaas,
- Georg Fuernau,
- Oana Brosteanu,
- Dirk Hasenclever,
- Kai Zacharowski,
- Patrick Meybohm,
- RIPHeart-Study Collaborators
Affiliations
- Sabine Westphal
- Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt
- Christian Stoppe
- Department of Anaesthesiology, Medical Faculty, RWTH Aachen, University Aachen
- Matthias Gruenewald
- Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein
- Berthold Bein
- Department of Anaesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, Asklepios Klinik St. Georg
- Jochen Renner
- Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein
- Jochen Cremer
- Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein
- Mark Coburn
- Department of Anaesthesiology, Medical Faculty, RWTH Aachen, University Aachen
- Gereon Schaelte
- Department of Anaesthesiology, Medical Faculty, RWTH Aachen, University Aachen
- Andreas Boening
- Department of Cardiovascular Surgery, University of Giessen
- Bernd Niemann
- Department of Cardiovascular Surgery, University of Giessen
- Frank Kletzin
- Clinic of Anaesthesiology and Intensive Care Medicine, University Hospital Rostock
- Jan Roesner
- Department of Anaesthesiology and Intensive Care, Suedstadt Hospital Rostock
- Ulrich Strouhal
- Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt
- Christian Reyher
- Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt
- Rita Laufenberg-Feldmann
- Department of Anesthesiology, Medical Center of Johannes Gutenberg-University
- Marion Ferner
- Department of Anesthesiology, Medical Center of Johannes Gutenberg-University
- Ivo F. Brandes
- Department of Anaesthesiology and Intensive Care Medicine, University Hospital Goettingen
- Martin Bauer
- Department of Anaesthesiology and Intensive Care, Klinikum Region Hannover
- Andreas Kortgen
- Department of Anaesthesiology and Intensive Care Medicine and Center for Sepsis Control and Care, Jena University Hospital
- Sebastian N. Stehr
- Department of Anesthesiology and Intensive Care Medicine, University Hospital Leipzig
- Maria Wittmann
- Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn
- Georg Baumgarten
- Department of Anaesthesiology and Intensive Care Medicine, Johanniter Hospital Bonn
- Rafael Struck
- Department of Anaesthesiology and Intensive Care Medicine, University Hospital Bonn
- Tanja Meyer-Treschan
- Department of Anaesthesiology and Intensive Care Medicine, University Hospital Duesseldorf
- Peter Kienbaum
- Department of Anaesthesiology and Intensive Care Medicine, University Hospital Duesseldorf
- Matthias Heringlake
- Department of Anaesthesiology and Intensive Care Medicine, University Luebeck
- Julika Schoen
- Department of Anaesthesiology and Intensive Care Medicine, Hospital Neuruppin
- Michael Sander
- Department of Anaesthesiology and Intensive Care, University of Giessen
- Sascha Treskatsch
- Department of Anaesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin
- Thorsten Smul
- Department of Anaesthesiology, University Hospital Wuerzburg
- Ewa Wolwender
- Department of Anaesthesiology, University Hospital Wuerzburg
- Thomas Schilling
- Department of Anaesthesiology, University Hospital Wuerzburg
- Frauke Degenhardt
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein
- Andre Franke
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein
- Soeren Mucha
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein
- Lukas Tittmann
- Institute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein
- Madeline Kohlhaas
- Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt
- Georg Fuernau
- University Heart Center Luebeck, Medical Clinic II (Cardiology/Angiology/Intensive Care Medicine), University Hospital Schleswig-Holstein, Luebeck
- Oana Brosteanu
- Clinical Trial Centre, University Leipzig
- Dirk Hasenclever
- Institute for Medical Informatics, Statistics and Epidemiology, University Leipzig
- Kai Zacharowski
- Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt
- Patrick Meybohm
- Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt
- RIPHeart-Study Collaborators
- DOI
- https://doi.org/10.1186/s12872-019-1002-x
- Journal volume & issue
-
Vol. 19,
no. 1
pp. 1 – 12
Abstract
Abstract Background The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. Methods We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery. Results A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10− 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10− 5 from the GWAS. Conclusions We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery. Trial registration The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.
Keywords
- Genome-wide association study
- Cardiac surgery
- Atrial fibrillation
- Delirium
- Myocardial infarction
- Acute kidney injury
