Nature Communications (Nov 2022)
Multi-omics signatures of the human early life exposome
- Léa Maitre,
- Mariona Bustamante,
- Carles Hernández-Ferrer,
- Denise Thiel,
- Chung-Ho E. Lau,
- Alexandros P. Siskos,
- Marta Vives-Usano,
- Carlos Ruiz-Arenas,
- Dolors Pelegrí-Sisó,
- Oliver Robinson,
- Dan Mason,
- John Wright,
- Solène Cadiou,
- Rémy Slama,
- Barbara Heude,
- Maribel Casas,
- Jordi Sunyer,
- Eleni Z. Papadopoulou,
- Kristine B. Gutzkow,
- Sandra Andrusaityte,
- Regina Grazuleviciene,
- Marina Vafeiadi,
- Leda Chatzi,
- Amrit K. Sakhi,
- Cathrine Thomsen,
- Ibon Tamayo,
- Mark Nieuwenhuijsen,
- Jose Urquiza,
- Eva Borràs,
- Eduard Sabidó,
- Inés Quintela,
- Ángel Carracedo,
- Xavier Estivill,
- Muireann Coen,
- Juan R. González,
- Hector C. Keun,
- Martine Vrijheid
Affiliations
- Léa Maitre
- Institute for Global Health (ISGlobal)
- Mariona Bustamante
- Institute for Global Health (ISGlobal)
- Carles Hernández-Ferrer
- Institute for Global Health (ISGlobal)
- Denise Thiel
- Department of Mathematics, Imperial College London
- Chung-Ho E. Lau
- MRC Centre for Environment and Health, School of Public Health, Imperial College London
- Alexandros P. Siskos
- Cancer Metabolism & Systems Toxicology Group, Division of Cancer, Department of Surgery & Cancer, Imperial College London
- Marta Vives-Usano
- Institute for Global Health (ISGlobal)
- Carlos Ruiz-Arenas
- Institute for Global Health (ISGlobal)
- Dolors Pelegrí-Sisó
- Institute for Global Health (ISGlobal)
- Oliver Robinson
- MRC Centre for Environment and Health, School of Public Health, Imperial College London
- Dan Mason
- Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust
- John Wright
- Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust
- Solène Cadiou
- Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences (IAB), Inserm, CNRS, Université Grenoble Alpes
- Rémy Slama
- Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Institute for Advanced Biosciences (IAB), Inserm, CNRS, Université Grenoble Alpes
- Barbara Heude
- Centre for Research in Epidemiology and Statistics (CRESS), Inserm, Université de Paris
- Maribel Casas
- Institute for Global Health (ISGlobal)
- Jordi Sunyer
- Institute for Global Health (ISGlobal)
- Eleni Z. Papadopoulou
- Division of Climate and Environmental Health, Norwegian Institute of Public Health
- Kristine B. Gutzkow
- Division of Climate and Environmental Health, Norwegian Institute of Public Health
- Sandra Andrusaityte
- Department of Environmental Sciences, Vytautas Magnus University
- Regina Grazuleviciene
- Department of Environmental Sciences, Vytautas Magnus University
- Marina Vafeiadi
- Department of Social Medicine, Faculty of Medicine, University of Crete
- Leda Chatzi
- Department of Population and Public Health Sciences, University of Southern California
- Amrit K. Sakhi
- Division of Climate and Environmental Health, Norwegian Institute of Public Health
- Cathrine Thomsen
- Division of Climate and Environmental Health, Norwegian Institute of Public Health
- Ibon Tamayo
- Computational Biology program, CIMA-University of Navarra
- Mark Nieuwenhuijsen
- Institute for Global Health (ISGlobal)
- Jose Urquiza
- Institute for Global Health (ISGlobal)
- Eva Borràs
- Universitat Pompeu Fabra (UPF)
- Eduard Sabidó
- Universitat Pompeu Fabra (UPF)
- Inés Quintela
- Medicine Genomics Group, Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER), University of Santiago de Compostela, CIMUS
- Ángel Carracedo
- Medicine Genomics Group, Centro de Investigación Biomédica en Red Enfermedades Raras (CIBERER), University of Santiago de Compostela, CIMUS
- Xavier Estivill
- Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology
- Muireann Coen
- Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Juan R. González
- Institute for Global Health (ISGlobal)
- Hector C. Keun
- Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London
- Martine Vrijheid
- Institute for Global Health (ISGlobal)
- DOI
- https://doi.org/10.1038/s41467-022-34422-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Environmental exposures in early life can have lasting health effects, but the molecular mechanisms are not well understood. Here, the authors discover >1000 associations between exposure factors and child multi-omics profiles, revealing signatures for diet, toxic chemical compounds, essential trace elements, and weather conditions.
