A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature

Noa Bigman-Peer; Eyal Peer; Barak Pertzov; Mordechai Kramer; Gad Segal; Noa Eliakim-Raz

doi:10.12890/2022_003502

European Journal of Case Reports in Internal Medicine (Aug 2022)

A Biphasic COVID-19 Clinical Course in Anti-CD20 Treated Patients: Case Series and Review of the Literature

Noa Bigman-Peer,
Eyal Peer,
Barak Pertzov,
Mordechai Kramer,
Gad Segal,
Noa Eliakim-Raz

Affiliations

Noa Bigman-Peer: Department of Internal Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
Eyal Peer: Oncology Institute, Sheba Medical Center, Ramat Gan, Israel
Barak Pertzov: Pulmonary Division, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
Mordechai Kramer: Pulmonary Division, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Gad Segal: Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Internal Medicine I, Sheba Medical Center, Ramat Gan, Israel
Noa Eliakim-Raz: Department of Internal Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel

DOI: https://doi.org/10.12890/2022_003502

Abstract

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We describe four cases of COVID-19 infection during the Omicron wave, in patients treated with anti-CD20 monoclonal antibodies. All cases follow a similar biphasic clinical course consisting of respiratory deterioration, which occurred a few weeks after convalescence from initial mild to asymptomatic infection. Possible explanations are discussed.

Published in European Journal of Case Reports in Internal Medicine

ISSN: 2284-2594 (Online)
Publisher: SMC MEDIA SRL
Country of publisher: Italy
LCC subjects: Medicine
Website: http://www.ejcrim.com

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Abstract

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