SPF45/RBM17-dependent splicing and multidrug resistance to cancer chemotherapy

Abstract

The early splicing complex A occupies at least eighty nucleotides of intron, in which U2AF covers the polypyrimidine tract. SPF45 (RBM17) functionally substitutes for U2AF on a subset of short introns. Since SPF45 expression confers resistance to various anticancer drugs, SPF45-dependent splicing may play a critical role in multidrug resistance.

Keywords

• pre-mrna splicing
• short intron
• spf45 (rbm17)
• u2af heterodimer
• anticancer drug resistance