Nature Communications (Jul 2022)
Multi-modal molecular programs regulate melanoma cell state
- Miles C. Andrews,
- Junna Oba,
- Chang-Jiun Wu,
- Haifeng Zhu,
- Tatiana Karpinets,
- Caitlin A. Creasy,
- Marie-Andrée Forget,
- Xiaoxing Yu,
- Xingzhi Song,
- Xizeng Mao,
- A. Gordon Robertson,
- Gabriele Romano,
- Peng Li,
- Elizabeth M. Burton,
- Yiling Lu,
- Robert Szczepaniak Sloane,
- Khalida M. Wani,
- Kunal Rai,
- Alexander J. Lazar,
- Lauren E. Haydu,
- Matias A. Bustos,
- Jianjun Shen,
- Yueping Chen,
- Margaret B. Morgan,
- Jennifer A. Wargo,
- Lawrence N. Kwong,
- Cara L. Haymaker,
- Elizabeth A. Grimm,
- Patrick Hwu,
- Dave S. B. Hoon,
- Jianhua Zhang,
- Jeffrey E. Gershenwald,
- Michael A. Davies,
- P. Andrew Futreal,
- Chantale Bernatchez,
- Scott E. Woodman
Affiliations
- Miles C. Andrews
- Department of Medicine, Monash University
- Junna Oba
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Chang-Jiun Wu
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Haifeng Zhu
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Tatiana Karpinets
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Caitlin A. Creasy
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Marie-Andrée Forget
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Xiaoxing Yu
- Department of Extended Intelligence for Medicine, The Ishii-Ishibashi Laboratory, Keio University School of Medicine
- Xingzhi Song
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Xizeng Mao
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- A. Gordon Robertson
- Canada’s Michael Smith Genome Sciences Center, BC Cancer
- Gabriele Romano
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Peng Li
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Elizabeth M. Burton
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Yiling Lu
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Robert Szczepaniak Sloane
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Khalida M. Wani
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Kunal Rai
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Alexander J. Lazar
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Lauren E. Haydu
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Matias A. Bustos
- Departments of Translational Molecular Medicine and Genomic Sequencing Center, St John’s Cancer Institute, Providence Saint John’s Health Center
- Jianjun Shen
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
- Yueping Chen
- Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center
- Margaret B. Morgan
- Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center
- Jennifer A. Wargo
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Lawrence N. Kwong
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Cara L. Haymaker
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Elizabeth A. Grimm
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Patrick Hwu
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Dave S. B. Hoon
- Departments of Translational Molecular Medicine and Genomic Sequencing Center, St John’s Cancer Institute, Providence Saint John’s Health Center
- Jianhua Zhang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Jeffrey E. Gershenwald
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Michael A. Davies
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- P. Andrew Futreal
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Chantale Bernatchez
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Scott E. Woodman
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-022-31510-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
The regulation of the distinct intrinsic phenotypic states in melanoma remain poorly characterised. Here, multi-omics analysis for a panel of 68 early passage melanoma cell lines reveals that cancer cell intrinsic transcriptomic programs are associated with distinct immune features.
