Expression of MED28 in oral squamous cell carcinoma and para-carcinoma tissues and its correlation with clinical characteristics

Abstract

Objective To investigate the expression of mediator complex subunit 28 protein (MED28) in oral squamous cell carcinoma (OSCC) and para-carcinoma tissues, and its correlation with pathological features and prognosis. Methods A total of 142 OSCC specimens were collected from the inpatients undergoing surgical treatment in our department from January 2015 to June 2020. Among these specimens, 91 had para-carcinoma tissues. Immunohistochemistry was used to detect the MED28 expression in OSCC and para-carcinoma paraffin sections. Chi-square test was used to analyze the difference of MED28 expression between OSCC and para-carcinoma tissues. The patients were then divided into MED28-high and MED28-low expression groups according to its median expression level. Logistic regression model was used to analyze the relationship between MED28 expression and pathological features, Kaplan-Meier survival analysis was selected to study the relationship between the expression and prognosis, and COX regression analysis was employed to analyze the prognostic factors. Results MED28 was significantly highly expressed in the OSCC tissues than para-carcinoma tissues (P < 0.01). Logistic regression model showed that MED28 expression is related with smoking and lymph node metastasis(P < 0.05). Kaplan-Meier survival analysis indicated that overall survival (OS) in the patients was significantly higher in the MED28-low expression group than the MED28-high expression group (P < 0.01). Gender and smoking status were identified as related factors influencing prognosis (P < 0.05). Conclusion MED28 is highly expressed in the OSCC tissues, which might be related to the occurrence and development of OSCC. It also affects the prognosis, and is related to smoking status and lymph node metastasis.

Keywords

• oral squamous cell carcinoma
• med28
• pathological feature
• prognosis