Nature Communications (May 2021)
Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
- Emily L. Giddings,
- Devin P. Champagne,
- Meng-Han Wu,
- Joshua M. Laffin,
- Tina M. Thornton,
- Felipe Valenca-Pereira,
- Rachel Culp-Hill,
- Karen A. Fortner,
- Natalia Romero,
- James East,
- Phoebe Cao,
- Hugo Arias-Pulido,
- Karatatiwant S. Sidhu,
- Brian Silverstrim,
- Yoonseok Kam,
- Shana Kelley,
- Mark Pereira,
- Susan E. Bates,
- Janice Y. Bunn,
- Steven N. Fiering,
- Dwight E. Matthews,
- Robert W. Robey,
- Domink Stich,
- Angelo D’Alessandro,
- Mercedes Rincon
Affiliations
- Emily L. Giddings
- Division of Immunobiology, Department of Medicine, Larner College of Medicine, University of Vermont
- Devin P. Champagne
- Division of Immunobiology, Department of Medicine, Larner College of Medicine, University of Vermont
- Meng-Han Wu
- Department of Immunology and Microbiology, University of Colorado Denver, Anschutz Medical Campus
- Joshua M. Laffin
- Division of Immunobiology, Department of Medicine, Larner College of Medicine, University of Vermont
- Tina M. Thornton
- Division of Immunobiology, Department of Medicine, Larner College of Medicine, University of Vermont
- Felipe Valenca-Pereira
- Department of Immunology and Microbiology, University of Colorado Denver, Anschutz Medical Campus
- Rachel Culp-Hill
- Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus
- Karen A. Fortner
- Division of Immunobiology, Department of Medicine, Larner College of Medicine, University of Vermont
- Natalia Romero
- Cell Analysis Division, Agilent Technologies
- James East
- Division of Immunobiology, Department of Medicine, Larner College of Medicine, University of Vermont
- Phoebe Cao
- Department of Immunology and Microbiology, University of Colorado Denver, Anschutz Medical Campus
- Hugo Arias-Pulido
- Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College
- Karatatiwant S. Sidhu
- Department of Chemistry, University of Vermont
- Brian Silverstrim
- Division of Immunobiology, Department of Medicine, Larner College of Medicine, University of Vermont
- Yoonseok Kam
- Cell Analysis Division, Agilent Technologies
- Shana Kelley
- Department of Pharmaceutical Sciences, University of Toronto
- Mark Pereira
- Department of Pharmaceutical Sciences, University of Toronto
- Susan E. Bates
- Division of Hematology/Oncology, Columbia University Medical Center
- Janice Y. Bunn
- Department of Medical Biostatistics, University of Vermont
- Steven N. Fiering
- Department of Microbiology and Immunology, Geisel School of Medicine, Dartmouth College
- Dwight E. Matthews
- Department of Chemistry, University of Vermont
- Robert W. Robey
- Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health
- Domink Stich
- Advanced Light Microscopy Core, Neurotechnology Center, University of Colorado Denver, Anschutz Medical Campus
- Angelo D’Alessandro
- Department of Biochemistry and Molecular Genetics, University of Colorado Denver, Anschutz Medical Campus
- Mercedes Rincon
- Division of Immunobiology, Department of Medicine, Larner College of Medicine, University of Vermont
- DOI
- https://doi.org/10.1038/s41467-021-23071-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 19
Abstract
Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes chemoresistance in preclinical cancer models.
