Body mass index and mortality following primary graft dysfunction: A Lung Transplant Outcomes Group study

Rachel M. Bennett, MD; John P. Reilly, MD MS; Joshua M. Diamond, MD MS; Edward Cantu, MD MS; Michael Shashaty, MD MS; Luke Benvenuto, MD; Jonathan P. Singer, MD MS; Scott M. Palmer, MD MS; Jason D. Christie, MD MS; Michaela R. Anderson, MD MS

JHLT Open (Aug 2024)

Body mass index and mortality following primary graft dysfunction: A Lung Transplant Outcomes Group study

Rachel M. Bennett, MD,
John P. Reilly, MD MS,
Joshua M. Diamond, MD MS,
Edward Cantu, MD MS,
Michael Shashaty, MD MS,
Luke Benvenuto, MD,
Jonathan P. Singer, MD MS,
Scott M. Palmer, MD MS,
Jason D. Christie, MD MS,
Michaela R. Anderson, MD MS

Affiliations

Rachel M. Bennett, MD: Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania
John P. Reilly, MD MS: Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania
Joshua M. Diamond, MD MS: Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania
Edward Cantu, MD MS: Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania
Michael Shashaty, MD MS: Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania
Luke Benvenuto, MD: Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, Columbia University, New York, New York
Jonathan P. Singer, MD MS: Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California
Scott M. Palmer, MD MS: Department of Medicine, Division of Pulmonary Medicine, Duke University, Durham, North Carolina
Jason D. Christie, MD MS: Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania
Michaela R. Anderson, MD MS: Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania; Corresponding author: Michaela R. Anderson, MD MS, University of Pennsylvania Perelman School of Medicine, 3400 Spruce Street, Gates 9W 09062, Philadelphia, PA 19104.

Journal volume & issue: Vol. 5
p. 100107

Abstract

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Higher body mass index (BMI) increases the risk of developing primary graft dysfunction (PGD) after lung transplantation; whether BMI is associated with decreased survival after PGD is unknown. We utilized the Lung Transplant Outcomes Group cohort of 1,538 subjects from 2011-2018. We evaluated the association between preoperative BMI and graft survival among subjects with severe PGD using Cox proportional hazards models with linear splines. Models were stratified by center and adjusted for sex, age, Lung Allocation Score, and diagnosis. PGD developed in 383 subjects. Among subjects with PGD, low BMI was associated with increased mortality while high BMI was not associated with differential mortality, compared to normal BMI. Results were similar for 90-day and 1-year survival. While high BMI increases the risk of developing PGD, it does not appear to be associated with survival after PGD. Future work should focus on PGD prevention rather than PGD management in patients with obesity.

Published in JHLT Open

ISSN: 2950-1334 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Surgery; Medicine: Internal medicine: Specialties of internal medicine
Website: https://www.sciencedirect.com/journal/jhlt-open

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Abstract

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