Molecules (May 2006)

Synthesis of Novel Sterically Demanding Carbo- and Heterocyclic β-Ketoesters

  • Peter Stanetty,
  • Thomas C. M. Fischer,
  • Marko D. Mihovilovic

DOI
https://doi.org/10.3390/11050357
Journal volume & issue
Vol. 11, no. 5
pp. 357 – 364

Abstract

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We present an easy method for the synthesis of β-ketoesters starting from variouscarbocyclic and heterocyclic carboxylic acids and esters. The β-ketoester side-chain wasintroduced by a sequence involving α-deprotonation and quenching with CO2, conversion tothe corresponding acid chloride and subsequent chain elongation using deprotonated ethylacetate.

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