Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits

Mahul Chakraborty; J. J. Emerson; Stuart J. Macdonald; Anthony D. Long

doi:10.1038/s41467-019-12884-1

Nature Communications (Oct 2019)

Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits

Mahul Chakraborty,
J. J. Emerson,
Stuart J. Macdonald,
Anthony D. Long

Affiliations

Mahul Chakraborty: Department of Ecology and Evolutionary Biology, University of California Irvine
J. J. Emerson: Department of Ecology and Evolutionary Biology, University of California Irvine
Stuart J. Macdonald: Department of Molecular Biosciences, University of Kansas
Anthony D. Long: Department of Ecology and Evolutionary Biology, University of California Irvine

DOI: https://doi.org/10.1038/s41467-019-12884-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Rare structural variants may account for a significant fraction of variation in complex traits. Here the authors analyse 14 Drosophila melanogaster genomes and find that structural variants are common, found in functionally important genes, and associated with QTLs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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