Clinical and Translational Allergy (Oct 2022)
An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium
- Margitta Worm,
- Aikaterina Alexiou,
- Veronika Höfer,
- Till Birkner,
- Alexander C. S. N. Jeanrenaud,
- Florent Fauchère,
- Kristijan Pazur,
- Carolin Steinert,
- Aleix Arnau‐Soler,
- Priyanka Banerjee,
- Andreas Diefenbach,
- Josefine Dobbertin‐Welsch,
- Sabine Dölle‐Bierke,
- Wojciech Francuzik,
- Ahla Ghauri,
- Stephanie Heller,
- Birgit Kalb,
- Ulrike Löber,
- Ingo Marenholz,
- Lajos Markó,
- Jörg Scheffel,
- Olena Potapenko,
- Stephanie Roll,
- Susanne Lau,
- Young‐Ae Lee,
- Julian Braun,
- Andreas Thiel,
- Magda Babina,
- Sabine Altrichter,
- Sofia Kirke Forslund,
- Kirsten Beyer
Affiliations
- Margitta Worm
- Division of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Aikaterina Alexiou
- Division of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Veronika Höfer
- Division of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Till Birkner
- Experimental and Clinical Research Center A Cooperation of Charité‐Universitätsmedizin Berlin Max Delbrück Center for Molecular Medicine Berlin Germany
- Alexander C. S. N. Jeanrenaud
- Max Delbrück Center for Molecular Medicine Helmholtz Association Berlin Germany
- Florent Fauchère
- Si‐M/“Der Simulierte Mensch” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin Berlin Germany
- Kristijan Pazur
- Division of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Carolin Steinert
- Institute of Allergology IFA Charité‐Universitätsmedizin Berlin Freie Universität Berlin Humboldt‐Universität zu Berlin Berlin Institute of Health Berlin Germany
- Aleix Arnau‐Soler
- Max Delbrück Center for Molecular Medicine Helmholtz Association Berlin Germany
- Priyanka Banerjee
- Institute of Physiology Charité – Universitätsmedizin Berlin Freie Universität Berlin Humboldt‐Universität zu Berlin Berlin Institute of Health Berlin Germany
- Andreas Diefenbach
- Mucosal and Developmental Immunology German Rheuma Research Center Berlin (DRFZ) Berlin Germany
- Josefine Dobbertin‐Welsch
- Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Sabine Dölle‐Bierke
- Division of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Wojciech Francuzik
- Division of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Ahla Ghauri
- Max Delbrück Center for Molecular Medicine Helmholtz Association Berlin Germany
- Stephanie Heller
- Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Birgit Kalb
- Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Ulrike Löber
- Experimental and Clinical Research Center A Cooperation of Charité‐Universitätsmedizin Berlin Max Delbrück Center for Molecular Medicine Berlin Germany
- Ingo Marenholz
- Max Delbrück Center for Molecular Medicine Helmholtz Association Berlin Germany
- Lajos Markó
- Experimental and Clinical Research Center A Cooperation of Charité‐Universitätsmedizin Berlin Max Delbrück Center for Molecular Medicine Berlin Germany
- Jörg Scheffel
- Institute of Allergology IFA Charité‐Universitätsmedizin Berlin Freie Universität Berlin Humboldt‐Universität zu Berlin Berlin Institute of Health Berlin Germany
- Olena Potapenko
- Experimental and Clinical Research Center A Cooperation of Charité‐Universitätsmedizin Berlin Max Delbrück Center for Molecular Medicine Berlin Germany
- Stephanie Roll
- Institute of Social Medicine, Epidemiology and Health Economics Charité—Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Susanne Lau
- Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Young‐Ae Lee
- Max Delbrück Center for Molecular Medicine Helmholtz Association Berlin Germany
- Julian Braun
- Si‐M/“Der Simulierte Mensch” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin Berlin Germany
- Andreas Thiel
- Si‐M/“Der Simulierte Mensch” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin Berlin Germany
- Magda Babina
- Institute of Allergology IFA Charité‐Universitätsmedizin Berlin Freie Universität Berlin Humboldt‐Universität zu Berlin Berlin Institute of Health Berlin Germany
- Sabine Altrichter
- Institute of Allergology IFA Charité‐Universitätsmedizin Berlin Freie Universität Berlin Humboldt‐Universität zu Berlin Berlin Institute of Health Berlin Germany
- Sofia Kirke Forslund
- Experimental and Clinical Research Center A Cooperation of Charité‐Universitätsmedizin Berlin Max Delbrück Center for Molecular Medicine Berlin Germany
- Kirsten Beyer
- Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- DOI
- https://doi.org/10.1002/clt2.12197
- Journal volume & issue
-
Vol. 12,
no. 10
pp. n/a – n/a
Abstract
Background Peanut allergy is a frequent cause of food allergy and potentially life‐threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non‐allergic controls. Methods Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen‐reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. Results We identified combined cellular and soluble biomarker signatures that stratify donors into peanut‐allergic and non‐allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. Conclusion By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies.
Keywords
