A case of autoimmune epilepsy associated with anti-leucine-rich glioma inactivated subunit 1 antibodies manifesting electrical shock-like sensations and transparent sadness

Yoshiko Murata; Osamu Watanabe; Go Taniguchi; Daichi Sone; Mao Fujioka; Mitsutoshi Okazaki; Eiji Nakagawa; Yutaka Watanabe; Masako Watanabe

doi:10.1016/j.ebcr.2015.08.004

Epilepsy and Behavior Case Reports (Jan 2015)

A case of autoimmune epilepsy associated with anti-leucine-rich glioma inactivated subunit 1 antibodies manifesting electrical shock-like sensations and transparent sadness

Yoshiko Murata,
Osamu Watanabe,
Go Taniguchi,
Daichi Sone,
Mao Fujioka,
Mitsutoshi Okazaki,
Eiji Nakagawa,
Yutaka Watanabe,
Masako Watanabe

Affiliations

Yoshiko Murata: Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Japan
Osamu Watanabe: Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
Go Taniguchi: Department of Neuropsychiatry, The University of Tokyo Hospital, Japan
Daichi Sone: Department of Neuropsychiatry, The University of Tokyo Hospital, Japan
Mao Fujioka: Department of Neuropsychiatry, The University of Tokyo Hospital, Japan
Mitsutoshi Okazaki: Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Japan
Eiji Nakagawa: Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Japan
Yutaka Watanabe: Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Japan
Masako Watanabe: Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Japan

DOI: https://doi.org/10.1016/j.ebcr.2015.08.004
Journal volume & issue: Vol. 4, no. C
pp. 91 – 93

Abstract

Read online

Autoimmune epilepsy is an isolated phenotype of autoimmune encephalitis, which may be suspected in patients with unexplained adult-onset seizure disorders or resistance to antiepileptic drugs (AEDs). Antibodies against leucine-rich glioma inactivated subunit 1 of the voltage-gated potassium channel (VGKC) complex, recently termed anti-LGI-1 antibodies, are one of the causes of autoimmune epilepsies. Bizarre symptoms with extremely short duration and high frequency are clues to the possible presence of autoimmune epilepsy with anti-LGI-1 antibodies. Precise diagnosis is important because autoimmune epilepsy is treatable and the prognosis can be predicted.

Published in Epilepsy and Behavior Case Reports

ISSN: 2213-3232 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.journals.elsevier.com/epilepsy-and-behavior-case-reports/

About the journal

Abstract

Keywords