Self-Assembly of Human Serum Albumin: A Simplex Phenomenon

Abstract

Spontaneous self-assemblies of biomolecules can generate geometrical patterns. Our findings provide an insight into the mechanism of self-assembled ring pattern generation by human serum albumin (HSA). The self-assembly is a process guided by kinetic and thermodynamic parameters. The generated protein ring patterns display a behavior which is geometrically related to a n-simplex model and is explained through thermodynamics and chemical kinetics.

Keywords

• protein self-assembly
• Pascal’s triangle
• n-simplex
• geometric pattern
• thermodynamics
• kinetics