Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development

Sze Jing Tang; Haoqing Shen; Omer An; HuiQi Hong; Jia Li; Yangyang Song; Jian Han; Daryl Jin Tai Tay; Vanessa Hui En Ng; Fernando Bellido Molias; Ka Wai Leong; Priyankaa Pitcheshwar; Henry Yang; Leilei Chen

doi:10.1038/s41467-020-14621-5

Nature Communications (Feb 2020)

Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development

Sze Jing Tang,
Haoqing Shen,
Omer An,
HuiQi Hong,
Jia Li,
Yangyang Song,
Jian Han,
Daryl Jin Tai Tay,
Vanessa Hui En Ng,
Fernando Bellido Molias,
Ka Wai Leong,
Priyankaa Pitcheshwar,
Henry Yang,
Leilei Chen

Affiliations

Sze Jing Tang: Cancer Science Institute of Singapore, National University of Singapore
Haoqing Shen: Cancer Science Institute of Singapore, National University of Singapore
Omer An: Cancer Science Institute of Singapore, National University of Singapore
HuiQi Hong: Cancer Science Institute of Singapore, National University of Singapore
Jia Li: Cancer Science Institute of Singapore, National University of Singapore
Yangyang Song: Cancer Science Institute of Singapore, National University of Singapore
Jian Han: Cancer Science Institute of Singapore, National University of Singapore
Daryl Jin Tai Tay: Cancer Science Institute of Singapore, National University of Singapore
Vanessa Hui En Ng: Cancer Science Institute of Singapore, National University of Singapore
Fernando Bellido Molias: Cancer Science Institute of Singapore, National University of Singapore
Ka Wai Leong: Cancer Science Institute of Singapore, National University of Singapore
Priyankaa Pitcheshwar: Cancer Science Institute of Singapore, National University of Singapore
Henry Yang: Cancer Science Institute of Singapore, National University of Singapore
Leilei Chen: Cancer Science Institute of Singapore, National University of Singapore

DOI: https://doi.org/10.1038/s41467-020-14621-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

Read online

RNA editing and RNA splicing are involved in tumorigenesis. Here the authors report crosstalk between RNA editing and splicing by identifying ADAR1/2-dependent splicing events in esophageal squamous carcinoma cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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