Stroke Research and Treatment (Jan 2020)
Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the VENOST Study
- Derya Uluduz,
- Sevki Sahin,
- Taskin Duman,
- Serefnur Ozturk,
- Vildan Yayla,
- Nazire Afsar,
- Nevzat Uzuner,
- Ipek Midi,
- Nilgun Cinar,
- Mehmet Ali Sungur,
- Fusun Mayda Domac,
- Birsen Ince,
- Baki Goksan,
- Cemile Handan Misirli,
- Mustafa Bakar,
- Hasan Huseyin Kozak,
- Sena Colakoglu,
- Ali Yavuz Karahan,
- Eylem Ozaydin Goksu,
- Fatih Ozdag,
- Mehmet Guney Senol,
- Vedat Ali Yurekli,
- Ufuk Aluclu,
- Serkan Demir,
- Hayriye Kucukoglu,
- Serdar Oruc,
- Nilufer Yesilot,
- Ozge Yimaz Kusbeci,
- Bijen Nazliel,
- Firdevs Ezgi Ucan Tokuc,
- Hesna Bektas,
- Fatma Nida Tascilar,
- Emrah Aytac,
- Mustafa Gokce,
- Hale Zeynep Batur Caglayan,
- Ahmet Tufekci,
- Gulnur Uzuner,
- Dilek Necioglu Orken,
- Osman Ozgur Yalin,
- Uygar Utku,
- Arda Yilmaz,
- Hamit Genc,
- Murat Cabalar,
- Aysel Milanlioglu,
- Hakan Ekmekci,
- Burcu Zeydan,
- Sevim Baybas,
- Yuksel Kablan,
- Basak Karakurum Goksel,
- Mustafa Acikgoz,
- Hatice Kurucu,
- Seden Demirci,
- Taskin Gunes
Affiliations
- Derya Uluduz
- School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey
- Sevki Sahin
- School of Medicine, Department of Neurology, Maltepe University, Istanbul, Turkey
- Taskin Duman
- School of Medicine, Department of Neurology, Mustafa Kemal University, Hatay, Turkey
- Serefnur Ozturk
- Selcuk University, School of Medicine, Department of Neurology, Konya, Turkey
- Vildan Yayla
- University of Health Science, Hamidiye School of Medicine, Sadi Konuk Research and Training Hospital, Department of Neurology, Istanbul, Turkey
- Nazire Afsar
- Acibadem University, School of Medicine, Department of Neurology, Istanbul, Turkey
- Nevzat Uzuner
- Osmangazi University, School of Medicine, Department of Neurology, Eskisehir, Turkey
- Ipek Midi
- Marmara University, School of Medicine, Department of Neurology, Istanbul, Turkey
- Nilgun Cinar
- School of Medicine, Department of Neurology, Maltepe University, Istanbul, Turkey
- Mehmet Ali Sungur
- Duzce University, School of Medicine, Department of Biostatistics, Duzce, Turkey
- Fusun Mayda Domac
- University of Health Science, Hamidiye School of Medicine, Erenkoy Research and Training Hospital for Neurologic and Psychiatric Diseases, Department of Neurology, Istanbul, Turkey
- Birsen Ince
- School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey
- Baki Goksan
- School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey
- Cemile Handan Misirli
- University of Health Science, Hamidiye School of Medicine, Haydarpasa Training and Research Hospital, Department of Neurology, Istanbul, Turkey
- Mustafa Bakar
- Uludag University, School of Medicine, Department of Neurology, Bursa, Turkey
- Hasan Huseyin Kozak
- Nemettin Erbakan University, School of Medicine, Department of Neurology, Konya, Turkey
- Sena Colakoglu
- School of Medicine, Department of Neurology, Mustafa Kemal University, Hatay, Turkey
- Ali Yavuz Karahan
- Usak University, School of Medicine, Department of Physical Medicine and Rehabilitation, Usak, Turkey
- Eylem Ozaydin Goksu
- Antalya Research and Training Hospital, Clinic of Neurology, Antalya, Turkey
- Fatih Ozdag
- University of Health Science, Hamidiye School of Medicine, Sultan Abdulhamid Han Research and Training Hospital, Department of Neurology, Istanbul, Turkey
- Mehmet Guney Senol
- University of Health Science, Hamidiye School of Medicine, Sultan Abdulhamid Han Research and Training Hospital, Department of Neurology, Istanbul, Turkey
- Vedat Ali Yurekli
- Suleyman Demirel University, School of Medicine, Department of Neurology, Isparta, Turkey
- Ufuk Aluclu
- Dicle University, School of Medicine, Department of Neurology, Diyarbakır, Turkey
- Serkan Demir
- Sancaktepe Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey
- Hayriye Kucukoglu
- Sultan Abdulhamid Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey
- Serdar Oruc
- Kocatepe University, School of Medicine, Department of Neurology, Afyon, Turkey
- Nilufer Yesilot
- Istanbul University, School of Medicine, Department of Neurology, Istanbul, Turkey
- Ozge Yimaz Kusbeci
- Bozyaka Education, Research and Traning Hospital, Clinic of Neurology, Izmir, Turkey
- Bijen Nazliel
- Gazi University, School of Medicine, Department of Neurology, Ankara, Turkey
- Firdevs Ezgi Ucan Tokuc
- Antalya Research and Training Hospital, Clinic of Neurology, Antalya, Turkey
- Hesna Bektas
- Ataturk Research and Training Hospital, Clinic of Neurology, Ankara, Turkey
- Fatma Nida Tascilar
- Bulent Ecevit University, School of Medicine, Department of Neurology, Zonguldak, Turkey
- Emrah Aytac
- Firat University, School of Medicine, Department of Neurology, Elazig, Turkey
- Mustafa Gokce
- Sutcu Imam University, School of Medicine, Department of Neurology, Kahramanmaras, Turkey
- Hale Zeynep Batur Caglayan
- Gazi University, School of Medicine, Department of Neurology, Ankara, Turkey
- Ahmet Tufekci
- Recep Tayyip Erdogan University, School of Medicine, Department of Neurology, Rize, Turkey
- Gulnur Uzuner
- Osmangazi University, School of Medicine, Department of Neurology, Eskisehir, Turkey
- Dilek Necioglu Orken
- Bilim University, School of Medicine, Department of Neurology, Istanbul, Turkey
- Osman Ozgur Yalin
- Istanbul Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey
- Uygar Utku
- Sutcu Imam University, School of Medicine, Department of Neurology, Kahramanmaras, Turkey
- Arda Yilmaz
- Mersin University, School of Medicine, Department of Neurology, Mersin, Turkey
- Hamit Genc
- Mersin University, School of Medicine, Department of Neurology, Mersin, Turkey
- Murat Cabalar
- Sadi Konuk Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey
- Aysel Milanlioglu
- Yuzuncu Yil University, School of Medicine, Department of Neurology, Van, Turkey
- Hakan Ekmekci
- Selcuk University, School of Medicine, Department of Neurology, Konya, Turkey
- Burcu Zeydan
- Mayo Clinic, College of Medicine, Department of Neurology, Rochester, MN., USA
- Sevim Baybas
- Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurology Training and Research Hospital, Clinic of Neurology, Istanbul, Turkey
- Yuksel Kablan
- Inonu University, School of Medicine, Department of Neurology, Malatya, Turkey
- Basak Karakurum Goksel
- Baskent University, School of Medicine, Department of Neurology, Ankara, Turkey
- Mustafa Acikgoz
- Bulent Ecevit University, School of Medicine, Department of Neurology, Zonguldak, Turkey
- Hatice Kurucu
- School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey
- Seden Demirci
- Akdeniz University, School of Medicine, Department of Neurology, Antalya, Turkey
- Taskin Gunes
- Maltepe Government Hospital, Clinic of Neurology, Istanbul, Turkey
- DOI
- https://doi.org/10.1155/2020/8610903
- Journal volume & issue
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Vol. 2020
Abstract
Background. Early diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelae; thus, the symptoms must be documented in detail for each group. Methods. Out of 1144 patients with CVST, a total of 777 women were enrolled from a multicenter for the study of cerebral venous sinus thrombosis (VENOST). Demographic, biochemical, clinical, and radiological aspects were compared for 324 cases with RHRF and 453 cases without RHRF. Results. The mean age of the RHRF (-) group (43.2 ± 13 years) was significantly higher than of the RHRF (+) group (34±9 years). A previous history of deep venous thrombosis (3%), isolated cavernous sinus involvement (1%), cranial neuropathy (13%), comorbid malignancy (7%), and its disability scores after 12 months (9%) were significantly higher in the RHRF (-) group. The RHRF (+) group consisted of 44% cases of puerperium, 33% cases of OC users and 23% of pregnant women. The mean age was found to be higher in OC users (38±9 years). A previous history of deep venous thrombosis was slightly higher in the pregnancy subgroup (4%). Epileptic seizures were more common in the puerperium group (44%). Conclusion. The results of our study indicate that the risk of CSVT increases parallel to age, OC use, and puerperium period. In addition, when considering the frequency of findings and symptoms, epileptic seizures in the puerperium subgroup of the RHRF (+) group and malignancies in the RHRF (-) group may accompany the CSVT. In daily practice, predicting these risks for the CSVT and early recognition of the symptoms will provide significant benefits to patients.
